Chiral Anion-Induced Catalytic Asymmetric Direct Dehydrative Coupling of 3-Vinylindoles and 3-Indolylmethanols
Chiral Anion-Induced Catalytic Asymmetric Direct Dehydrative Coupling of 3-Vinylindoles and 3-Indolylmethanols
复制标题
手性阴离子诱导催化 3-乙烯基吲哚和 3-吲哚甲醇的不对称直接脱水偶联
DOI：
10.1002/adsc.201801705
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发表时间：
2019-04-16
影响因子：
5.4
通讯作者：
Guo, Qi-Xiang
中科院分区：
文献类型：
--
作者：
Li, Xiao-Yun;Hu, Wei-Ting;Guo, Qi-Xiang
烯烃与醇的催化直接脱水偶联是形成Csp(2)-Csp(2)键的最直接和最环保的策略之一。然而，先前报道的研究只涉及非手性反应。本文研究了手性Bronsted酸催化的3-乙烯基吲哚和3-吲哚甲醇的直接催化不对称脱水偶联反应。以优异的收率和良好的立体选择性制备了多种结构多样的吲哚化合物。
The catalytic direct dehydrative coupling of an alkene with an alcohol is one of the most straightforward and green strategies for the formation of Csp(2)-Csp(2) bonds. However, previously reported studies have only dealt with achiral reactions. Here, we describe chiral Bronsted acid-catalyzed direct catalytic asymmetric dehydrative coupling reactions of 3-vinylindoles and 3-indolylmethanols. Various structurally diverse indole compounds were prepared in good to excellent yields, with good to excellent stereoselectivities.