Age-Adjusted Incidence, Mortality, and Survival Rates of Stage-Specific Renal Cell Carcinoma in North America: A Trend Analysis
Age-Adjusted Incidence, Mortality, and Survival Rates of Stage-Specific Renal Cell Carcinoma in North America: A Trend Analysis
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DOI：
10.1016/j.eururo.2010.10.029
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发表时间：
2011-01-01
期刊：
影响因子：
23.4
通讯作者：
Karakiewicz, Pierre I.
中科院分区：
文献类型：
--
作者：
Sun, Maxine;Thuret, Rodolphe;Karakiewicz, Pierre I.
背景资料：肾细胞癌（RCC）的发病率不断上升，在很大程度上归因于越来越多地使用成像processing.Objective：我们的目的是研究阶段特异性的发病率，死亡率和生存趋势的RCC在北美。设计，设置，和参与者：我们计算年龄调整的发病率，生存率和死亡率使用的监测流行病学和最终结果数据库。在1988年至2006年期间，43807例经组织学证实的肾细胞癌患者被纳入研究。测量：我们计算了每年的发病率、死亡率和5年生存率。结果和局限性：RCC的经统计学调整的发病率从1988年的7.6/10万人年上升到2006年的11.7/10万人年（估计的年百分比变化[ EAPC]：+2.39%; p < 0.001）。局限期的分期特异性年龄调整发病率增加：1988年为3.8，2006年为8.2（EAPC：+4.29%; p < 0.001），而同期远端期的发病率下降：2.1至1.6（EAPC：-0.57%; p = 0.01）。局部分期的分期特异性生存率随着时间的推移而提高，但区域和远处分期的分期特异性生存率保持稳定。在研究期间，局部期死亡率变化显著，1988年为1.3%，2006年为2.4%（EAPC：+3.16%; p < 0.001），远处期死亡率为1.8%，1988年为1.8%，2006年为1.6%（EAPC：-0.53%; p = 0.045）。更详细的分期信息代表了一个主要的限制study.Conclusions：本地RCC的发病率迅速增加，而那些遥远的RCC下降。局部期死亡率显著增加，远处期死亡率显著降低。RCC的诊断和管理仍需创新。(C)2010年欧洲泌尿外科协会。Elsevier B. V.出版，保留所有权利。
Background: The rising incidence of renal cell carcinoma (RCC) has been largely attributed to the increasing use of imaging procedures.Objective: Our aim was to examine stage-specific incidence, mortality, and survival trends of RCC in North America.Design, setting, and participants: We computed age-adjusted incidence, survival, and mortality rates using the Surveillance Epidemiology and End Results database. Between 1988 and 2006, 43 807 patients with histologically confirmed RCC were included.Measurements: We calculated incidence, mortality, and 5-yr survival rates by year. Reported findings were stratified according to disease stage.Results and limitations: Age-adjusted incidence rate of RCC rose from 7.6 per 100 000 person-years in 1988 to 11.7 in 2006 (estimated annual percentage change [ EAPC]: +2.39%; p < 0.001). Stage-specific age-adjusted incidence rates increased for localized stage: 3.8 in 1988 to 8.2 in 2006 (EAPC: +4.29%; p < 0.001) and decreased during the same period for distant stage: 2.1 to 1.6 (EAPC: -0.57%; p = 0.01). Stage-specific survival rates improved over time for localized stage but remained stable for regional and distant stages. Mortality rates varied significantly over the study period among localized stage, 1.3 in 1988 to 2.4 in 2006 (EAPC: +3.16%; p < 0.001), and distant stage, 1.8 in 1988 to 1.6 in 2006 (EAPC: -0.53%; p = 0.045). Better detailed staging information represents a main limitation of the study.Conclusions: The incidence rates of localized RCC increased rapidly, whereas those of distant RCC declined. Mortality rates significantly increased for localized stage and decreased for distant stage. Innovation in diagnosis and management of RCC remains necessary. (C) 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.