Enhanced T-helper 2 lymphocyte responses: Immune mechanism of Helicobacter pylori infection
Enhanced T-helper 2 lymphocyte responses: Immune mechanism of Helicobacter pylori infection
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DOI：
10.1007/bf02942800
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发表时间：
1996-01-01
影响因子：
2.1
通讯作者：
Keeling, PWN
中科院分区：
文献类型：
--
作者：
Fan, XG;Yakoob, J;Keeling, PWN
多项证据表明幽门螺杆菌（H. pylori）感染与胃十二指肠炎症有关。然而，幽门螺杆菌感染的确切发病机制尚不完全清楚，根据细胞因子产生的不同模式，辅助性T（TH）淋巴细胞可能被细分为TH1和TH2细胞，TH1反应与免疫或对感染的抵抗力有关，而TH2反应与感染的进展或持续有关，1型细胞因子干扰素-γ（INF-γ）和白细胞介素2（IL-2）的产生在幽门螺杆菌感染中减少。幽门螺杆菌感染，在幽门螺杆菌感染个体中观察到 2 型细胞因子（IL-4）和 IL-6）产生增强，在幽门螺杆菌定植患者中也证实了外周血和胃淋巴细胞的增殖反应受到抑制，表明特异性 T 细胞反应可能被增强的 TH2 反应下调。幽门螺杆菌感染。
Several lines of evidence implicate Helicobacter pylori (H. pylori) infection in gastroduodenal inflammation. However, the exact pathogenesis of H. pylori infection is not fully understood, T-helper (TH) lymphocytes may be subdivided into TH1 and TH2 cells based on the distinct patterns of cytokine production, TH1 reaction is associated with immunity or resistance to infection, while TH2 reaction is associated with the progression or persistence of infection, The production of interferon-gamma (INF-gamma) and interleukin 2 (IL-2), which are type 1 cytokines, is decreased in H. pylori infection, Enhanced production of type 2 cytokines (IL-4) and IL-6) is observed in individuals with H. pylori infection, Suppressed proliferative responses of peripheral blood and gastric lymphocytes have also been demonstrated in patients with H. pylori colonisation, suggesting that specific T-cell responses may be down-regulated by an enhanced TH2 reaction, Suppressed TH1 and enhanced TH2 responses in H. pylori infection may be involved in the immunopathogenesis of chronic H. pylori infection.