Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo
Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo
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DOI：
10.1111/j.1460-9568.2005.04537.x
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发表时间：
2006-01-01
影响因子：
3.4
通讯作者：
van der Kooy, D
中科院分区：
文献类型：
--
作者：
Coles, BLK;Horsford, DJ;van der Kooy, D
视网膜干细胞[具有产生神经视网膜祖细胞或视网膜色素上皮（RPE）祖细胞的潜力]存在于哺乳动物的眼睛中，并且确实干细胞群体的最大绝对增加发生在出生后。干细胞在胚胎期增殖，因此可能有助于最初建立视网膜，但在出生后的哺乳动物中，它们显然不会增殖以再生视网膜以应对损伤。使用Chx 10（orJ/orJ）和Mitf（mi/mi）小鼠，由于神经视网膜祖细胞群和视网膜色素上皮祖细胞群的减少，分别具有小眼表型，我们现在报告，视网膜干细胞群，当从睫状缘测定时，在两种突变体中增加3-8倍。这些发现表明，哺乳动物视网膜干细胞群体可能能够响应来自祖细胞群体的遗传诱导信号。
Retinal stem cells [with the potential to produce either neural retinal progenitors or retinal pigment epithelial (RPE) progenitors] exist in the mammalian eye throughout life, and indeed the greatest absolute increase in the stem population occurs postnatally. The stem cells proliferate embryonically and thus may help to build the retina initially, but in postnatal mammals they clearly do not proliferate to regenerate the retina in response to injury. Using Chx10(orJ/orJ) and Mitf(mi/mi) mice, with small eye phenotypes due to the reduction of the neural retinal progenitor population and the retinal pigmented epithelial progenitor population, respectively, we now report that the retinal stem cell population, when assayed from the ciliary margin, increases 3-8-fold in both mutants. These findings suggest that the mammalian retinal stem cell population may be capable of responding to genetically induced signals from the progenitor populations.