Modular Construction of Fluorescent Lipophosphoramidates by Click Chemistry
Modular Construction of Fluorescent Lipophosphoramidates by Click Chemistry
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DOI：
10.1002/ejoc.201100900
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发表时间：
2011-11-01
影响因子：
2.8
通讯作者：
Jaffres, Paul-Alain
中科院分区：
文献类型：
--
作者：
Berchel, Mathieu;Haelters, Jean-Pierre;Jaffres, Paul-Alain
报道了荧光脂磷酰胺的合成。它们的模块化结构允许分子结构的多种变化，包括通过短亚甲基或四甘醇间隔基将荧光探针与脂磷酰胺部分分开。聚合合成的最后一步是 Huisgen 点击反应，它将荧光探针与脂磷酰胺部分组装起来。本研究考虑了五种荧光探针，包括香豆素、NBD、荧光素、萘酰亚胺和花青。
The synthesis of fluorescent lipophosphoramidates is reported. Their modular construction allows several variations of the molecular structure including the separation of the fluorescent probe from the lipophosphoramidate moiety by a short methylene or by a tetraethylene glycol spacer. The last step of the convergent synthesis is a Huisgen click reaction, which assembles the fluorescent probe with the lipophosphoramidate part. Five fluorescent probes have been considered in this study including coumarin, NBD, fluorescein, naphthalimide and cyanine.