Maturation of retroviruses
Maturation of retroviruses
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DOI：
10.1016/j.coviro.2019.05.004
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发表时间：
2019-06-01
影响因子：
5.9
通讯作者：
Ganser-Pornillos, Barbie K.
中科院分区：
文献类型：
--
作者：
Pornillos, Owen;Ganser-Pornillos, Barbie K.
在逆转录病毒成熟过程中，病毒蛋白酶对前体结构Gag多蛋白的切割诱导了病毒颗粒的结构重排，使其从未成熟的形态转变为成熟的、具有传染性的形态。这种结构重排将病毒RNA基因组封装在富勒烯衣壳中，产生可扩散的病毒核，该病毒核可在进入宿主细胞的细胞质时启动感染。成熟是对抗HIV-1的重要治疗窗口。在这篇综述中，我们重点介绍了逆转录病毒未成熟和成熟衣壳晶格结构的最新突破，这些结构定义了成熟的边界条件，并为衣壳转化提供了新的见解。我们还讨论了关于病毒基因组在成熟衣壳中的衣壳化的新见解，以及有待进一步研究的问题。
During retrovirus maturation, cleavage of the precursor structural Gag polyprotein by the viral protease induces architectural rearrangement of the virus particle from an immature into a mature, infectious form. The structural rearrangement encapsidates the viral RNA genome in a fullerene capsid, producing a diffusible viral core that can initiate infection upon entry into the cytoplasm of a host cell. Maturation is an important therapeutic window against HIV-1. In this review, we highlight recent breakthroughs in understanding of the structures of retroviral immature and mature capsid lattices that define the boundary conditions of maturation and provide novel insights on capsid transformation. We also discuss emerging insights on encapsidation of the viral genome in the mature capsid, as well as remaining questions for further study.