Seizures among families of Indian probands with different epileptic syndromes
Seizures among families of Indian probands with different epileptic syndromes
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DOI：
10.1046/j.1600-0404.2003.00252.x
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发表时间：
2004-07-01
影响因子：
3.5
通讯作者：
Pandey, RM
中科院分区：
文献类型：
--
作者：
Jain, S;Bhatia, M;Pandey, RM
目的：探讨遗传因素在不同癫痫综合征病因中的作用。材料和方法-发生癫痫发作之间的第一和第二度的亲属5628印度先证者与癫痫，和3357先证者与非癫痫神经系统疾病（谁作为对照人群）进行了记录。癫痫先证者和受影响的亲属之间的症状一致性进行了调查。结果：20%的癫痫先证者（1129例）有亲属受累。与非癫痫先证者的亲属相比，癫痫先证者的亲属更容易受到影响（OR：3.4）。一些癫痫综合征的先证者往往有阳性家族史。年轻先证者的亲属患癫痫的风险更大。与其他一级和二级亲属相比，同胞更容易受到影响（OR：1.3和4.6）。与二级亲属相比，具有全身性癫痫和综合征以及热性惊厥（FC）的同胞与先证者的综合征一致性几率更大。与有症状的癫痫患者相比，患有特发性/隐源性癫痫的同胞和二级亲属具有更大的一致性几率。结论：五分之一的所有类型癫痫综合征的先证者都有癫痫发作的家族史。癫痫的家族风险与先证者的癫痫综合征及其发病年龄相关。亲属受影响的风险因与先证者的关系而异。癫痫综合征的一致性作为癫痫综合征的函数和与先证者的关系而变化。
Objectives - To investigate the contribution of hereditary factors in the causation of different epilepsy syndromes. Material and methods - Occurrence of seizures among first- and second-degree relatives of 5628 Indian probands with epilepsy, and 3357 probands with non-epilepsy neurological disorders (who acted as control population) was documented. Syndromic concordance between epilepsy probands and affected relatives was investigated. Results - Twenty percent epilepsy probands (1129) had affected relatives. Relatives of epilepsy probands were more often affected compared with relatives of non-epilepsy probands (OR: 3.4). Probands with some epilepsy syndromes more often had a positive family history. Relatives of younger probands were at greater risk of having epilepsy. Sibs were more often affected compared with other first- and second-degree relatives (OR: 1.3 and 4.6). Sibs having generalized epilepsies and syndromes and febrile convulsions (FC) were at greater odds of syndromic concordance with probands compared with second-degree relatives. Sibs and second-degree relatives having idiopathic/cryptogenic epilepsy had greater odds for concordance compared with those with symptomatic epilepsies. Conclusions - One-fifth of probands with all types of epileptic syndromes have family history of seizures. Familial risk of epilepsy correlated with the epilepsy syndrome among probands and their age at presentation. Risk of relatives being affected varied as a function of the relation with probands. Concordance of epilepsy syndromes varied both as a function of the epilepsy syndrome and relation with the probands.