The value of resting-state functional magnetic resonance imaging for detecting epileptogenic zones in patients with focal epilepsy.
The value of resting-state functional magnetic resonance imaging for detecting epileptogenic zones in patients with focal epilepsy.
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DOI：
10.1371/journal.pone.0172094
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Yin J
中科院分区：
文献类型：
--
作者：
Chen Z;An Y;Zhao B;Yang W;Yu Q;Cai L;Ni H;Yin J
探讨静息态功能磁共振成像（RS-fMRI）局部分析方法区域均匀性（ReHo）、低频波动幅度（ALFF）和低频波动分数（fALFF）对癫痫灶（EZ）的诊断价值。共入组了42例连续的局灶性癫痫患者。评价视觉评估的RS-fMRI、MRI、磁共振波谱（MRS）、视频脑电图（VEEG）和正电子发射断层扫描计算机断层扫描（PET-CT）在EZ定位中的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV），以评估其诊断能力。还比较了ReHo、ALFF和fALFF的诊断价值。对于局灶性癫痫患者的EZ定位，RS-fMRI显示与PET（83.3%）和VEEG（66.7%）相当的敏感性和特异性。RS-fMRI与其他定位技术在敏感性、特异性、PPV和NPV方面无显著差异。ReHo、ALFF和fALFF的敏感性分别为69.4%、52.8%和38.9%，特异性分别为66.7%、83.3%和66.7%。ReHo、ALFF和fALFF之间无显著差异，但ReHo比fALFF更敏感。RS-fMRI可能是检测局灶性癫痫患者EZs的有效工具。
To determine the value of resting-state functional magnetic resonance imaging (RS-fMRI) based on the local analysis methods regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional ALFF (fALFF), for detecting epileptogenic zones (EZs). A total of 42 consecutive patients with focal epilepsy were enrolled. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of visually assessed RS-fMRI, MRI, magnetic resonance spectroscopy (MRS), video electroencephalography (VEEG), and positron-emission tomography computed tomography (PET-CT) in EZ localization were evaluated to assess their diagnostic abilities. ReHo, ALFF, and fALFF were also compared for their diagnostic values. RS-fMRI showed comparable sensitivity to PET (83.3%) and specificity to VEEG (66.7%), respectively, for EZ localization in patients with focal epilepsy. There were no significant differences between RS-fMRI and the other localization techniques in terms of sensitivity, specificity, PPV, and NPV. The sensitivities of ReHo, ALFF, and fALFF were 69.4%, 52.8%, and 38.9%, respectively, and for specificities of 66.7%, 83.3%, and 66.7%, respectively. There were no significant differences among ReHo, ALFF, and fALFF, except that ReHo was more sensitive than fALFF. RS-fMRI may be an efficient tool for detecting EZs in focal epilepsy patients.