Nanomaterials in Humans: Identification, Characteristics, and Potential Damage
Nanomaterials in Humans: Identification, Characteristics, and Potential Damage
复制标题
人体纳米材料：识别、特性和潜在损害
DOI：
10.1177/0192623311413787
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发表时间：
2011-08-01
影响因子：
1.5
通讯作者：
Ma, Jing
中科院分区：
文献类型：
--
作者：
Song, Yuguo;Li, Xue;Ma, Jing
纳米材料越来越多地用于商业目的。然而，人们对暴露于人类的潜在风险感到担忧。我们之前报道了一组因职业接触喷漆而导致肺部疾病和死亡的患者。然而，暴露的纳米粒子和化学成分并没有得到充分的描述。本研究旨在分离和鉴定患者活检中观察到的纳米颗粒，并利用电子显微镜报告其对人体肺部的潜在有害影响。电镜和能量色散x射线分析发现，二氧化硅纳米颗粒主要存在于巨噬细胞、肺微血管、血管内皮细胞、微淋巴管、胸腔积液中，少量存在于肺泡上皮细胞和肺间质组织中（未见微尺度颗粒存在）。值得注意的是，观察到肺泡上皮细胞、巨噬细胞、血管内皮细胞和血气屏障的损伤。考虑到有充分证据证明的微型二氧化硅的毒性，这些二氧化硅纳米颗粒可能在一定程度上导致了这些工人报告的疾病。这种可能性支持采取控制和预防策略，以尽量减少工人吸入纳米粒子，并强调了人类纳米安全研究的迫切需要和重要性。
Nanomaterials are increasingly being used for commercial purposes. However, concerns about the potential risks of exposure to humans have been raised. We previously reported unusual pulmonary disease and death in a group of patients with occupational exposure to spray paint. However, the nanoparticle and chemical composition of the exposure was not fully described. The present study aimed to isolate and identify the nanoparticles observed in the patients' biopsies and report the potential deleterious effects to human lungs using electron microscopy. Using electron microscopy and energy dispersive x-ray analysis, silica nanoparticles were identified and characterized mainly in macrophages, pulmonary microvessels, vascular endothelial cells, microlymphatic vessels, pleural effusions, and a few in alveolar epithelial cells and pulmonary interstitial tissue (with no microscale particles present). Notably, damage to alveolar epithelial cells, macrophages, vascular endothelial cells, and the blood-gas barrier was observed. Given the well-documented toxicity of microscale silica, it is possible that these silica nanoparticles may have contributed in part to the illness reported in these workers. Such a possibility supports the adoption of controls and prevention strategies to minimize inhalation of nanoparticles by workers, and it highlights the urgent need and the importance of the nanosafety study in humans.