Case-control study of high risk occupations for bladder cancer in New Zealand
Case-control study of high risk occupations for bladder cancer in New Zealand
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DOI：
10.1002/ijc.23194
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发表时间：
2008-03-15
影响因子：
6.4
通讯作者：
Pearcei, Neil
中科院分区：
文献类型：
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作者：
Dryson, Evan;'t Mannetje, Andrea;Pearcei, Neil
我们对新西兰成年人的膀胱癌进行了一项全国范围的病例对照研究，以确定可能增加新西兰人口患膀胱癌风险的职业。 2003 年和 2004 年期间向新西兰癌症登记处通报的总共 213 例膀胱癌病例（年龄 25-70 岁）和 471 名人口对照者接受了面对面访谈。调查问卷收集了人口统计信息和完整的职业史。与曾受雇于特定职业和行业相关的膀胱癌相对风险是通过调整年龄、性别、吸烟和社会经济状况的无条件逻辑回归来计算的。随后对估计进行了半贝叶斯调整，以考虑到正在考虑的大量职业和行业。美发师（优势比 (OR) 9.15 95% 置信区间 (95% CI) 1.60-62.22）和缝纫机师（OR 3.07 95% CI 1.35-6.96）的膀胱癌风险较高。先前研究中报告的其他几种职业并未观察到风险显着增加，包括销售助理（OR 1.03 95% CI 0.64-1.67）、油漆工和裱纸工（OR 1.42 95% CI 0.56-3.60）、钣金工人（OR 0.39，95% CI 0.15-1.00）、印刷工人（OR 0.39，95% CI 0.15-1.00）。 1.11 95% CI 0.41-3.05）和 卡车司机（OR 1.36 95% CI 0.60-3.09），尽管油漆工、印刷工和卡车司机的比值比升高与其他研究中观察到的过度行为一致。裁缝和裁缝（OR 2.84 95% CI 0.62-13.05）、橡胶和塑料制品机器操作员（OR 2.82 95% CI 0.75-10.67）、建筑工人（OR 2.15，95% CI 0.68-6.73）以及女性市场农民和农作物种植者（OR 2.05）的风险没有显着增加。 95%置信区间 0.72-5.83）。总之，这项研究证实了新西兰理发师和缝纫机师是膀胱癌高危职业，并确定了其他几个值得进一步研究的膀胱癌高危职业和行业。 (C) 2007 Wiley-Liss, Inc.
We conducted a nationwide case-control study of bladder cancer in adult New Zealanders to identify occupations that may contribute to the risk of bladder cancer in the New Zealand population. A total of 213 incident cases of bladder cancer (age 25-70 years) notified to the New Zealand Cancer Registry during 2003 and 2004, and 471 population controls, were interviewed face-to-face. The questionnaire collected demographic information and a full occupational history. The relative risks for bladder cancer associated with ever being employed in particular occupations and industries were calculated by unconditional logistic regression adjusting for age, sex, smoking and socio-economic status. Estimates were subsequently semi-Bayes adjusted to account for the large number of occupations and industries being considered. An elevated bladder cancer risk was observed for,hairdressers (odds ratio (OR) 9.15 95% Confidence Interval (95% CI) 1.60-62.22), and sewing machinists (OR 3.07 95% CI 1.35-6.96). Significantly increased risks were not observed for several other occupations that have been reported in previous studies, including sales assistants (OR 1.03 95% CI 0.64-1.67), painters and paperhangers (OR 1.42 95% CI 0.56-3.60), sheet metal workers (OR 0.39, 95% CI 0.15-1.00), printing trades workers (OR 1.11 95% CI 0.41-3.05) and truck drivers (OR 1.36 95% CI 0.60-3.09), although the elevated odds ratios for painters, printers and truck drivers are consistent with excesses observed in other studies. Nonsignificantly increased risks were observed for tailors and dressmakers (OR 2.84 95% CI 0.62-13.05), rubber and plastics products machine operators (OR 2.82 95% CI 0.75-10.67), building workers (OR 2.15, 95% CI 0.68-6.73), and female market farmers and crop growers (OR 2.05 95% CI 0.72-5.83). In conclusion, this study has confirmed that hairdressers and sewing machinists are high risk occupations for bladder cancer in New Zealand, and has identified several other occupations and industries of high bladder cancer risk that merit further study. (C) 2007 Wiley-Liss, Inc.