An integrated mathematical model of the human cardiopulmonary system: model development
An integrated mathematical model of the human cardiopulmonary system: model development
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DOI：
10.1152/ajpheart.00230.2014
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发表时间：
2016-04-01
影响因子：
4.8
通讯作者：
Chbat, Nicolas W.
中科院分区：
文献类型：
--
作者：
Albanese, Antonio;Cheng, Limei;Chbat, Nicolas W.
在过去的几十年中，已经提出了几种心血管和肺模型。然而，很少有人讨论这两个系统之间的相互作用。我们的团队开发了一个综合心肺模型（CP模型），该模型从数学上描述了心血管和呼吸系统之间的相互作用，沿着它们的主要短期控制机制。该模型已与人类和动物的数据从已发表的文献进行了比较。由于工作量大，本文分为两部分。本文是关于模型开发和正常生理学，而第二个是关于模型在低氧和高碳酸条件下的验证。CP模型结合了心血管循环、呼吸力学、组织和肺泡气体交换以及作用于心血管和呼吸功能的短期神经控制机制。该模型能够模拟在正常和病理条件下通常在成年人中观察到的生理变量，并解释潜在的机制和动力学。
Several cardiovascular and pulmonary models have been proposed in the last few decades. However, very few have addressed the interactions between these two systems. Our group has developed an integrated cardiopulmonary model (CP Model) that mathematically describes the interactions between the cardiovascular and respiratory systems, along with their main short-term control mechanisms. The model has been compared with human and animal data taken from published literature. Due to the volume of the work, the paper is divided in two parts. The present paper is on model development and normophysiology, whereas the second is on the model's validation on hypoxic and hypercapnic conditions. The CP Model incorporates cardiovascular circulation, respiratory mechanics, tissue and alveolar gas exchange, as well as short-term neural control mechanisms acting on both the cardiovascular and the respiratory functions. The model is able to simulate physiological variables typically observed in adult humans under normal and pathological conditions and to explain the underlying mechanisms and dynamics.