Reformation of specific synaptic connections by regenerating sensory axons in the spinal cord of the bullfrog.
Reformation of specific synaptic connections by regenerating sensory axons in the spinal cord of the bullfrog.
复制标题
通过再生牛蛙脊髓中的感觉轴突来改造特定的突触连接。
DOI：
10.1007/bf02842934
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Sah,DW
中科院分区：
文献类型：
--
作者：
Frank,E;Sah,DW
The regrowth of sensory axons into the spinal cord of juvenile bullfrogs was studied after disruption of these fibers in the dorsal root. Within 9 d after the root had been frozen, regenerating sensory axons had reached the spinal cord, as revealed by labeling with horseradish peroxidase. Growth into the spinal cord, however, was much slower. Even several months after denervation, very few fibers had reestablished any of their normal longitudinal projections within the dorsal funiculus. Eventually, however, sensory axons grew across the region and into the dorsal horn. Intracellular recordings from motoneurons revealed that these axons made functional reconnections with spinal neurons. Muscle sensory axons established direct, monosynaptic inputs to motoneurons, whereas cutaneous fibers innervated these neurons polysynaptically. Moreover, sensory afferents from a particular muscle distinguished among different classes of motoneurons, just as in normal frogs. Thus, specific synaptic pathways can be reestablished by regenerating sensory axons if they can reach their appropriate target region within the spinal cord.
