SAFETY PROFILE OF ADENOSINE STRESS PERFUSION IMAGING - RESULTS FROM THE ADENOSCAN-MULTICENTER-TRIAL-REGISTRY
SAFETY PROFILE OF ADENOSINE STRESS PERFUSION IMAGING - RESULTS FROM THE ADENOSCAN-MULTICENTER-TRIAL-REGISTRY
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DOI：
10.1016/0735-1097(94)90424-3
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发表时间：
1994-02-01
影响因子：
24
通讯作者：
WILLIAMS, KA
中科院分区：
文献类型：
--
作者：
CERQUEIRA, MD;VERANI, MS;WILLIAMS, KA
目标。本研究的目的是确定9256例连续患者以140 μ g/kg / min的速度输注腺苷并结合放射性核素显像的安全性。腺苷直接产生最大心肌充血，起效迅速。此外，当与放射性核素灌注显像结合使用时，它已被证明对无法运动的患者的冠状动脉疾病的诊断有疗效。由于半衰期极短（70岁），发生房室传导阻滞的风险增加
Objectives. The purpose of this study was to determine the safety of adenosine infusion at 140 mu g/kg per min in conjunction with radionuclide imaging in 9,256 consecutive patients.Background. Adenosine produces maximal myocardial hyperemia directly with a rapid onset of action. In addition, when used in conjunction with radionuclide perfusion imaging, it has proven efficacy for the diagnosis of coronary artery disease in patients unable to exercise. Because the ultrashort half-life (70 years of age had an increased risk of developing AV block (age