Fruit and vegetable consumption and gastric cancer by location and histological type: case-control and meta-analysis
Fruit and vegetable consumption and gastric cancer by location and histological type: case-control and meta-analysis
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DOI：
10.1097/01.cej.0000236255.95769.22
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发表时间：
2007-08-01
影响因子：
2.4
通讯作者：
Barros, Henrique
中科院分区：
文献类型：
--
作者：
Lunet, Nuno;Valbuena, Carmen;Barros, Henrique
现有信息有利于;环境暴露对肠型胃癌的影响更大，贲门癌和远端胃癌的危险因素也似乎不同。我们的目的是评估水果和蔬菜摄入量与胃癌之间的关系，通过位置和组织学类型。我们进行了一项基于人群的病例对照研究和一项针对这一问题的研究荟萃分析。在两个大型教学医院（波尔图，葡萄牙）确定了事件病例（n=305），并在城市居民中随机抽样控制（n = 1129）。通过PubMed检索已发表的研究，并将效应与随机效应荟萃分析相结合。在我们的病例对照研究中，水果消费量最高与最低三分位数比较的比值比（OR）为0.47 [95%置信区间（CO：0.21-1.05），非贲门癌为0.53（95%CI：0.35-0.80），贲门癌为0.36（95%CI：0.21-1.05）（95% CI：0.20-0.62），弥漫型为1.00（95% CI：0.53-1.90）。蔬菜的OR值分别为0.59（95%CI：0.26-1.35）、0.85（95%CI：0.58-1.26）、0.95（95%CI：0.57-1.57）和0.60（95%CI：0.32-1.14）。在荟萃分析中，考虑到水果消费（最高与最低类别），合并OR为0.58（95% CI：0.38-0.89）对于贲门，0.61非贲门型为0.49（95%CI：0.33-0.72），弥漫型为0.82（95%CI：0.57-1.20）。蔬菜还降低了贲门癌（OR=0.63，95% CI：0.50-0.79）、非贲门癌（OR = 0.75，95% CI：0.59-0.95）、肠癌（OR = 0.61，95% CI：0.44-0-86）和弥漫型癌（OR= 0.67，95% CI：0.44-1.01）的风险。水果或蔬菜摄入量与胃癌风险降低相关，无论解剖位置和组织学类型如何，尽管饮食摄入量对肠道型癌症具有更明确的保护作用。
The available information favours; a greater impact of environmental exposures on intestinal type gastric cancer, and risk factors for the cardia and distal stomach cancers also appear to be different We aimed to estimate the association between fruit and vegetable intake and gastric cancer, by location and histological type. We performed a population-based case-control study and a meta-analysis of studies addressing this issue. Incident cases (n=305) were identified in two large teaching hospitals (Porto, Portugal), and controls were randomly sampled among city dwellers (n = 1129). Published studies were searched through PubMed, and effects were combined with random effects meta-analysis. In our case-control study, the odds ratio (OR) for the comparison of the highest vs. lowest tertile of fruit consumption was 0.47 [95% confidence interval (CO: 0.21-1.05] for cardia, 0.53 (95% Cl: 0.35-0.80) for non-cardia cancer, 0.36 (95% Cl: 0.20-0.62) for intestinal, and 1.00 (95% Cl: 0.53-1.90) for the diffuse histological type. For vegetables, the corresponding OR was 0.59 (95% Cl: 0.26-1.35),0.85 (95% Cl: 0.58-1.26),0.95 (95% Cl: 0.57-1.57), and 0.60 (95% Cl: 0.32-1.14). In meta-analysis, considering fruit consumption (highest vs. lowest category), the combined OR was 0.58 (95% Cl: 0.38-0.89) for cardia, 0.61 (95% Cl: 0.44-0.84) for non-cardia, 0.49 (95% Cl: 0.33-0.72) for intestinal type, and 0.82 (95% Cl: 0.57-1.20) for diffuse type. Vegetables also decreased the risk of cardia (OR=0.63, 95% Cl: 0.50-0.79), non-cardia (OR = 0.75, 95% Cl: 0.59-0.95), intestinal (OR = 0.61, 95% Cl: 0.44-0-86), and diffuse type (OR= 0.67,95% Cl: 0.44-1.01). Fruit or vegetable intake was associated with a decreased risk of gastric cancer regardless of the anatomical location and the histological type, although dietary intake had a more clear-cut protective effect on intestinal type cancers.