DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment
DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment
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DOI：
10.1212/01.wnl.0000153076.46126.e9
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发表时间：
2005-03-08
期刊：
影响因子：
9.9
通讯作者：
Jack, CR
中科院分区：
文献类型：
--
作者：
Kantarci, K;Petersen, RC;Jack, CR
作者评估了基线时测量海马水扩散率是否可以预测遗忘性轻度认知障碍(AMCI)患者未来发展为阿尔茨海默病(AD)。在急性心肌梗死患者中，基线海马区弥散系数越高，进展为AD的风险越大(p=0.002)。磁共振弥散加权成像可能有助于确定将进展为AD的aMCI患者，以及或优于结构MRI测量的海马区萎缩。
The authors assessed whether measures of hippocampal water diffusivity at baseline can predict future progression to Alzheimer disease (AD) in amnestic mild cognitive impairment (aMCI). Higher baseline hippocampal diffusivity was associated with a greater risk of progression to AD in aMCI (p = 0.002). Magnetic resonance diffusion-weighted imaging may help identify patients with aMCI who will progress to AD as well as or better than structural MRI measures of hippocampal atrophy.