Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer's disease.
Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer's disease.
复制标题
动脉自旋标记血流MRI：其在阿尔茨海默氏病早期表征中的作用。
DOI：
10.3233/jad-2010-091699
复制
发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Detre JA
中科院分区：
文献类型：
--
作者：
Alsop DC;Dai W;Grossman M;Detre JA
动脉自旋标记 (ASL) 可以使用标准磁共振成像 (MRI) 设备对脑血流进行无创定量成像。由于不需要注射造影剂，ASL 可以将静息功能信息添加到测量萎缩和缺血性损伤迹象的 MRI 研究中。描述了可能影响阿尔茨海默病研究的 ASL 技术的关键特征。回顾了描述 ASL 血流成像应用于阿尔茨海默病和相关痴呆的现有文献，并讨论了 ASL 在早期阿尔茨海默病治疗和预防研究中的潜在作用。
Arterial spin labeling (ASL) enables the noninvasive, quantitative imaging of cerebral blood flow using standard magnetic resonance imaging (MRI) equipment. Because it requires no contrast injection, ASL can add resting functional information to MRI studies measuring atrophy and signs of ischemic injury. Key features of ASL technology that may affect studies in Alzheimer’s disease are described. The existing literature describing ASL blood flow imaging applied to Alzheimer’s disease and related dementia is reviewed, and the potential role of ASL in treatment and prevention studies of early Alzheimer’s disease is discussed.