INDUCTION OF SUPEROVULATION AND PREGNANCY IN MATURE MICE BY GONADOTROPHINS
INDUCTION OF SUPEROVULATION AND PREGNANCY IN MATURE MICE BY GONADOTROPHINS
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DOI：
10.1677/joe.0.0150374
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发表时间：
1957-01-01
影响因子：
4
通讯作者：
EDWARDS, RG
中科院分区：
文献类型：
--
作者：
FOWLER, RE;EDWARDS, RG
用孕鼠血清和人绒毛膜促性腺激素诱导成年小鼠发情和超数排卵。在695只雌性动物中，514只对注射作出反应而交配; 99%的给药雌性动物排卵，75%的交配雌性动物怀孕。除正常卵外，还从雌性中回收了退化卵。有些雌性会产下大量的幼崽，尽管有些怀孕是不正常的。处理雌性的平均窝产仔数与自然动情期交配后发现的窝产仔数相似。使用促性腺激素进行一次以上治疗后，交配、排卵和妊娠的雌性动物数量少于第一次治疗后。
Estrus and superovulation were induced in adult mice (Mus musculus) by the injection of pregnant mares'' serum followed after 40 hours by human chorionic gonadotrophin. Of 695 females, 514 mated in response to the injections; 99% of the treated females ovulated and 75% of those which mated became pregnant.. Degenerated eggs were recovered from the females in addition to normal eggs. Some of the females gave birth to large litters, though some of the pregnancies were not normal. Mean litter size of the treated females was similar to that found after mating during natural estrus. After more than one treatment with gonadotrophins, fewer females mated, ovulated, and became pregnant than after the 1st treatment.