The Salivary IgA Flow Rate Is Increased by High Concentrations of Short-Chain Fatty Acids in the Cecum of Rats Ingesting Fructooligosaccharides.
The Salivary IgA Flow Rate Is Increased by High Concentrations of Short-Chain Fatty Acids in the Cecum of Rats Ingesting Fructooligosaccharides.
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DOI：
10.3390/nu8080500
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发表时间：
2016-08-17
期刊：
影响因子：
5.9
通讯作者：
Tsukinoki K
中科院分区：
文献类型：
--
作者：
Yamamoto Y;Takahahi T;To M;Nakagawa Y;Hayashi T;Shimizu T;Kamata Y;Saruta J;Tsukinoki K
唾液免疫球蛋白A（伊加）通过防止病原体的粘膜下侵入而作为粘膜免疫的主要效应物。然而，消费可发酵纤维增加唾液中伊加的机制尚未完全阐明。本研究探讨了低聚果糖（FOS）的摄入量和喂养时间对大鼠唾液和盲肠粘膜中伊加水平以及盲肠中短链脂肪酸（SCFA）浓度的影响。5周龄的大鼠分别喂食无纤维饮食或含50 g/kg FOS的饮食0、1、4和8周。在第一周和第八周摄入FOS导致单位重量下颌下腺组织的唾液伊加流量增加（p < 0.05），与盲肠粘膜SCFA浓度呈正相关（rs = 0.86，p = 0.0006，n = 12），但与盲肠粘膜伊加浓度无相关性（rs = 0.15，p = 0.3，n = 48）。这些结果表明，摄入FOS通过大肠中高水平的SCFA增加唾液伊加分泌，SCFA是由FOS发酵产生的。因此，连续摄入FOS一周以上可增加唾液伊加的分泌。
Salivary immunoglobulin A (IgA) serves as a major effector in mucosal immunity by preventing submucosal invasion of pathogens. However, the mechanism by which consumption of fermentable fibers increases IgA in saliva was not fully elucidated. This study investigated the effects of fructooligosaccharides (FOS) intake and time after feeding on IgA levels in the saliva and cecal digesta and on the concentration of short-chain fatty acids (SCFA) in the cecum in rats. Five-week-old rats were fed a fiber-free diet or a diet with 50 g/kg FOS for zero, one, four, and eight weeks. Ingestion of FOS at one and eight weeks led to a higher IgA flow rate of saliva per weight of submandibular gland tissue (p < 0.05), which positively correlated with the concentration of SCFA in the cecal digesta (rs = 0.86, p = 0.0006, n = 12), but showed no correlation with the concentration of IgA in the cecal digesta (rs = 0.15, p = 0.3, n = 48). These results suggested that ingestion of FOS increased salivary IgA secretion through high levels of SCFA in the large intestine, which was produced by fermentation of FOS. Thus, continuously ingesting FOS for more than one week could increase secretion of salivary IgA.