Serum Levels of Vitamin D, Sunlight Exposure, and Knee Cartilage Loss in Older Adults The Tasmanian Older Adult Cohort Study
Serum Levels of Vitamin D, Sunlight Exposure, and Knee Cartilage Loss in Older Adults The Tasmanian Older Adult Cohort Study
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DOI：
10.1002/art.24486
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发表时间：
2009-05-01
影响因子：
--
通讯作者：
Jones, Graeme
中科院分区：
文献类型：
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作者：
Ding, Changhai;Cicuttini, Flavia M.;Jones, Graeme
目标。目的：研究老年人血清维生素D水平、阳光暴晒与膝关节软骨横断面和纵向丢失之间的关系。共有880名随机选择的受试者(平均年龄61岁[范围51-79岁]，50%为女性)在基线时被研究，其中353名受试者在2.9年后被研究。采用放射免疫法测定血清25-羟基维生素D(25[OH]D)水平，采用问卷调查法评价日光照射情况。对右膝关节进行T1加权脂肪抑制磁共振成像(MRI)，以确定膝关节软骨的体积和缺损。检查膝关节放射学、骨性关节炎(OA)和膝关节疼痛情况。基线时25(OH)D平均水平为52.8nmoles/L(范围为13-119nmoles/L)。冬季日光照射和血清25(OH)D水平均与胫骨内侧和外侧软骨体积以及血清25(OH)D水平呈正相关
Objective. To determine the associations between serum levels of vitamin D, sunlight exposure, and knee cartilage loss cross-sectionally and longitudinally in older adults.Methods. A total of 880 randomly selected subjects (mean age 61 years [range 51-79 years], 50% women) were studied at baseline, and 353 of these subjects were studied 2.9 years later. Serum levels of 25-hydroxyvitamin D (25[OH]D) were assessed by radioimmunoassay, and sunlight exposure was assessed by questionnaire. T1-weighted fat-suppressed magnetic resonance imaging (MRI) of the right knee was performed to determine knee cartilage volume and defects. Knee radiographic osteoarthritis (OA) and knee pain were also assessed.Results. The mean 25(OH)D serum level was 52.8 nmoles/liter at baseline (range 13-119 nmoles/liter). Winter sunlight exposure and serum 25(OH)D level were both positively associated with medial and lateral tibial cartilage volume, and a serum 25(OH)D level