Coeliac disease and schizophrenia: population based case control study with linkage of Danish national registers
Coeliac disease and schizophrenia: population based case control study with linkage of Danish national registers
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DOI：
10.1136/bmj.328.7437.438
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发表时间：
2004-02-21
影响因子：
--
通讯作者：
Ewald, H
中科院分区：
文献类型：
--
作者：
Eaton, WW;Mortensen, PB;Ewald, H
多汉提出，遗传缺陷与麸质的环境触发因素相互作用会导致某些个体患上精神分裂症，并提供了支持性的流行病学证据。 1 一些临床试验和案例研究表明，不含谷物的饮食可以改善精神分裂症症状的缓解。 2 在乳糜泻研究中发现的最重要的遗传标记 (6p23-p22.3) 3 非常接近与精神分裂症有关的 Dysbindin 位点。 4
Dohan proposed that an inherited defect interacting with an environmental trigger of gluten precipitated schizophrenia in some individuals, and provided supportive epidemiological evidence. 1 Some clinical trials and case studies showed that a cereal free diet improved remission of symptoms of schizophrenia. 2 The most important genetic marker found in the study of coeliac disease (6p23-p22. 3) 3 is very close to the dysbindin locus, which has been implicated in schizophrenia. 4