Evolution of complex resistance transposons from an ancestral mercury transposon
Evolution of complex resistance transposons from an ancestral mercury transposon
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复杂抗性转座子从祖先汞转座子的进化
DOI：
10.1128/jb.153.3.1432-1438.1983
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发表时间：
1983
影响因子：
3.2
通讯作者：
T. Sawai
中科院分区：
文献类型：
--
作者：
M. Tanaka;T. Yamamoto;T. Sawai
转座子家族的分子相互关系，赋予多种抗生素耐药性，并假定已产生的祖先汞转座子进行了分析。最初，转座子Tn 2613（7.2个酶），编码汞抗性，和Tn 2608（13.5个酶），编码汞，链霉素，和磺胺类药物的抗性，被分离和它们的结构进行了分析。接下来，比较以下转座子的遗传和物理图谱：Tn 2613和Tn 501，编码汞抗性; Tn 2608和Tn 21，编码汞、链霉素和磺胺抗性; Tn 2607和Tn 4，编码链霉素、磺胺和氨苄青霉素抗性;以及Tn 2603，编码汞、链霉素、磺胺和氨苄青霉素抗性。结果表明，编码多重抗性的转座子是从祖先汞转座子进化而来的。
The molecular interrelationship of a transposon family which confers multiple antibiotic resistance and is assumed to have been generated from an ancestral mercury transposon was analyzed. Initially, the transposons Tn2613 (7.2 kilobases), encoding mercury resistance, and Tn2608 (13.5 kilobases), encoding mercury, streptomycin, and sulfonamide resistances, were isolated and their structures were analyzed. Next, the following transposons were compared with respect to their genetic and physical maps: Tn2613 and Tn501, encoding mercury resistance; Tn2608 and Tn21, encoding mercury, streptomycin, and sulfonamide resistance; Tn2607 and Tn4, encoding streptomycin, sulfonamide, and ampicillin resistance; and Tn2603, encoding mercury, streptomycin, sulfonamide, and ampicillin resistance. The results suggest that the transposons encoding multiple resistance were evolved from an ancestral mercury transposon.