Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance.
Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance.
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DOI：
10.3390/ijms19092835
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发表时间：
2018-09-19
影响因子：
5.6
通讯作者：
He B
中科院分区：
文献类型：
--
作者：
Giroux-Leprieur E;Costantini A;Ding VW;He B
Hedgehog信号通路在胚胎发育过程中被激活，尤其是在肺发育过程中。它也在许多实体瘤中被重新激活。在肺癌中，Hedgehog通路与癌症干细胞（CSC）密切相关。最近的工作表明，CSC产生全长Sonic Hedgehog（Shh）蛋白，具有旁分泌活性和诱导肿瘤发展。Hedgehog通路也参与了肺癌的耐药，如细胞毒化疗、放疗和靶向治疗。本文就Hedgehog信号通路在肺癌中的激活机制、其对克服耐药的临床意义以及进一步研究的展望作一综述。
Hedgehog signaling pathway is physiologically activated during embryogenesis, especially in lung development. It is also reactivated in many solid tumors. In lung cancer, Hedgehog pathway is closely associated with cancer stem cells (CSCs). Recent works have shown that CSCs produced a full-length Sonic Hedgehog (Shh) protein, with paracrine activity and induction of tumor development. Hedgehog pathway is also involved in tumor drug resistance in lung cancer, as cytotoxic chemotherapy, radiotherapy, and targeted therapies. This review proposes to describe the activation mechanisms of Hedgehog pathway in lung cancer, the clinical implications for overcoming drug resistance, and the perspectives for further research.
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通讯作者：
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通讯作者：
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