THE MARCKS FAMILY OF PROTEIN-KINASE-C SUBSTRATES
THE MARCKS FAMILY OF PROTEIN-KINASE-C SUBSTRATES
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DOI：
10.1042/bst0230587
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发表时间：
1995-08-01
影响因子：
3.9
通讯作者：
ADEREM, A
中科院分区：
文献类型：
--
作者：
ADEREM, A
豆蔻酰化富丙氨酸C激酶底物（MARCKS）是一种广泛分布的蛋白激酶C（PKC）底物，可结合钙调蛋白和肌动蛋白[1，2]，并与细胞运动、分泌、膜运输和有丝分裂有关（综述见[3，4]）。所有这些过程都需要调节肌动蛋白细胞骨架的重排。最近的结果表明，MARCKS在将细胞外信号转化为肌动蛋白可塑性的改变和肌动蛋白-膜相互作用的改变中起作用[31]。了解MARCKS结构，它与钙调蛋白，肌动蛋白和PKC的相互作用，以及它在膜和胞质溶胶之间循环的能力，为理解蛋白质的生物学作用提供了一个概念框架。
The myristoylated alanine-rich C kinase substrate (MARCKS) is a widely distributed protein kinase C (PKC) substrate that binds both calmodulin and actin [1, 2] and has been implicated in cell motility, secretion, membrane trafficking and mitogenesis (reviewed in [3, 4]). All these processes necessitate regulated rearrangement of the actin cytoskeleton. Recent results suggest that MARCKS has a role in translating extracellular signals into alterations in actin plasticity and changes in actin-membrane interactions [31. An understanding of MARCKS structure, of its interaction with calmodulin, actin and PKC, and of its capacity to cycle between the membrane and cytosol, provides a conceptual framework for understanding the biological role of the protein.