Brain pathology in systemic lupus erythematosus.
Brain pathology in systemic lupus erythematosus.
复制标题
系统性红斑狼疮的脑病理学。
作者：
J. Hanly;Walsh Nm;Sangalang
10例系统性红斑狼疮（SLE）患者的脑病理学记录，其中7例在死亡前有临床神经精神性SLE。表现为癫痫发作（5例患者）、器质性脑综合征（3例患者）和精神病（2例患者）。多灶性大脑皮质微梗死，与微血管损伤，记录在4例患者，在我们的研究构成了主要的组织病理学异常归因于系统性红斑狼疮。1例出现中等大小软脑膜血管的愈合性血管炎改变。在7/10例（70%）病例中观察到神经精神性SLE的临床和病理分类之间的一致性，最强的相关性是脑微梗死和癫痫发作之间的存在（4/5例患者，p <0.05）。与抗心磷脂、抗P、淋巴细胞毒性和抗神经元抗体无相关性。
Brain pathology was documented in 10 patients with systemic lupus erythematosus (SLE), 7 of whom had clinical neuropsychiatric SLE prior to death. This was manifested by seizures (5 patients), organic brain syndrome (3 patients) and psychosis (2 patients). Multifocal cerebral cortical microinfarcts, associated with microvascular injury, were documented in 4 patients and in our study constituted the predominant histopathologic abnormality attributable to SLE. Changes of a healed vasculitis in medium sized leptomeningeal vessels were seen in 1 case. Agreement between the clinical and pathologic classification of neuropsychiatric SLE was observed in 7/10 (70%) cases and the strongest association was between the presence of cerebral microinfarcts and seizures (4/5 patients, p less than 0.05). No correlation was observed with anticardiolipin, anti-P, lymphocytotoxic and antineuronal antibodies.