Time-restricted feeding regulates lipid metabolism under metabolic challenges.
Time-restricted feeding regulates lipid metabolism under metabolic challenges.
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限时喂养可调节代谢挑战下的脂质代谢。
DOI：
10.1002/bies.202300157
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Melkani,GirishC
中科院分区：
文献类型：
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作者：
Guo,Yiming;Livelo,Christopher;Melkani,GirishC
脂质代谢失调是一种与代谢综合征相关的常见特征，可导致负面健康结果的发展，如肥胖、糖尿病、非酒精性脂肪性肝病或动脉粥样硬化。限时喂养/进食（TRF/TRE）是一种新兴的饮食干预措施，已被证明可促进多种健康益处，包括改变与脂质代谢相关的基因的日表达，以及脂质种类的水平。尽管TRF可能在多个器官中引起反应，从而导致脂质代谢的调节，但大多数与TRF对脂质影响相关的研究仅关注于单个组织，而且缺乏对潜在机制的深入了解。在这篇综述中，我们总结了目前关于TRF对脂质代谢的影响以及脂肪组织、肝脏、骨骼肌和心脏的潜在机制，并概述了未来探索的可能途径。
Dysregulation of lipid metabolism is a commonly observed feature associated with metabolic syndrome and leads to the development of negative health outcomes such as obesity, diabetes mellitus, non‐alcoholic fatty liver disease, or atherosclerosis. Time‐restricted feeding/eating (TRF/TRE), an emerging dietary intervention, has been shown to promote pleiotropic health benefits including the alteration of diurnal expression of genes associated with lipid metabolism, as well as levels of lipid species. Although TRF likely induces a response in multiple organs leading to the modulation of lipid metabolism, a majority of the studies related to TRF effects on lipids have focused only on individual tissues, and furthermore there is a lack of insight into potential underlying mechanisms. In this review, we summarize the current insights regarding TRF effects on lipid metabolism and the potential mechanisms in adipose tissue, liver, skeletal muscle, and heart, and conclude by outlining possible avenues for future exploration.