The role of brain histamine in acute and chronic stresses
The role of brain histamine in acute and chronic stresses
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DOI：
10.1016/s0753-3322(00)80069-4
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发表时间：
2000-06-01
影响因子：
7.5
通讯作者：
Ito, C
中科院分区：
文献类型：
--
作者：
Ito, C
脑组胺作为一种神经递质或神经调节剂，在脑功能中具有多种生理作用。急性应激增加间脑、伏隔核和纹状体的组胺周转。组胺调节垂体前叶激素。抗焦虑药物也会减少脑组胺的周转。组胺H1受体拮抗剂和H3受体激动剂可降低焦虑状态。这些发现表明，急性压力会增加大脑组胺的周转，尤其是间脑，这可能部分与焦虑的病理有关。此外，慢性约束应激继续增加伏隔核和纹状体的组胺周转，而不是间脑。长期服用精神兴奋剂也会增加纹状体组胺的释放。组胺激动剂防止精神兴奋剂诱导的行为和行为致敏的发展。这些结果表明，慢性应激持续增加伏隔核和纹状体的组胺周转，这可能具有防止应激易感性的作用。此外，组胺H3受体拮抗剂具有抗抑郁作用。因此，间脑组胺周转的增加与抑郁状态的病理无关。(C) 2000年版《科学与医学》Elsevier SAS。
As a neurotransmitter or neuromodulator, brain histamine has a variety of physiological roles in brain functions. Acute stress increases the histamine turnovers in the diencephalon, nucleus accumbens and striatum. Histamine regulates anterior pituitary hormones. Anxiolytic drugs also decrease brain histamine turnover. Histamine H1 receptor antagonists and H3 receptor agonists decrease the anxiety state. These findings show that acute stresses increase brain histamine turnover, especially in the diencephalon, which would be partly related to the pathology of anxiety. Moreover, chronic restraint stress continued to increase the histamine turnovers in the nucleus accumbens and striatum, not in the diencephalon. Chronic administration of psychostimulants also increase the striatal histamine release. Histamine agonists prevent psychostimulant-induced behavior and the development of behavioral sensitization. These results indicate that chronic stress continues to increase the histamine turnovers in the nucleus accumbens and striatum, which would have a role of preventing stress vulnerability. Moreover, histamine H3 receptor antagonists have antidepressive effects. Therefore, no increase of histamine turnover in the diencephalon is related to the pathology of depressive state. (C) 2000 Editions scientifiques et medicales Elsevier SAS.