Serum uric acid level and its association with motor subtypes and non-motor symptoms in early Parkinson's disease: PALS study
Serum uric acid level and its association with motor subtypes and non-motor symptoms in early Parkinson's disease: PALS study
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DOI：
10.1016/j.parkreldis.2018.05.010
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发表时间：
2018-10-01
影响因子：
4.1
通讯作者：
Tan, Louis Chew-Seng
中科院分区：
文献类型：
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作者：
Huang, Xinxin;Ng, Samuel Yong-Ern;Tan, Louis Chew-Seng
目的：尿酸在帕金森病（PD）中具有潜在的神经保护作用。我们调查了血清尿酸水平和运动和非运动功能之间的关系，在一个前瞻性的早期PD cohort study.Methods：空腹血清尿酸水平测定125例早期PD患者。进行人口统计学、临床特征、运动和非运动评估。患者分为三种运动亚型：震颤主导型（TD）、姿势不稳定/步态困难（PIGD）和混合型。非运动症状被分类为存在或不存在的基础上适当的截止为每个non-motor instrument.Results：大多数患者TD（n = 51，40.8%）和混合（n = 63，50.4%）运动亚型，而少数有PIGD（n = 11，8.8%）运动亚型。三种运动亚型之间的平均血清尿酸水平存在显著差异（p = 0.0106），混合亚型的血清尿酸水平最低。使用TD亚型作为参考，血清尿酸水平较高的患者不太可能有混合（OR = 0.684; p = 0.0312）亚型，而不是TD亚型。尿酸水平在TD和PIGD亚型之间没有显著差异。结论：PD患者血清尿酸水平升高与TD运动亚型相关，与PD早期疲劳程度减轻相关，可能与其抗氧化能力有关。尿酸可能是PD患者特定运动特征和疲劳症状的重要生物标志物。
Objective: Uric acid has been found to be potentially neuroprotective in Parkinson's disease (PD). We investigated the relationship between serum uric acid levels and both motor and non-motor features in a prospective early PD cohort study.Methods: Fasting serum uric acid levels were measured from 125 early PD patients. Demographic, clinical characteristics, motor and non-motor assessments were performed. Patients were categorized into three motor subtypes: tremor-dominant (TD), postural instability/gait difficulty (PIGD), and mixed. Non-motor symptoms were classified as present or absent based on the appropriate cut-offs for each non-motor instrument.Results: Most patients had TD (n = 51, 40.8%) and mixed (n = 63, 50.4%) motor subtypes, while a minority had PIGD (n = 11, 8.8%) motor subtype. The mean serum uric acid levels were significantly different between the three motor subtypes (p = 0.0106), with the mixed subtype having the lowest serum uric acid levels. Using the TD subtype as reference, patients with higher serum uric acid levels were less likely to have the mixed (OR = 0.684; p = 0.0312) subtype as opposed to the TD subtype. Uric acid levels were not significantly different between the TD and PIGD subtypes. For non-motor symptoms, higher serum uric acid levels were significantly associated with less fatigue (OR = 0.693; p = 0.0408).Conclusion: Higher serum uric acid levels were associated with TD motor subtype and less fatigue in early PD, which could be related to its anti-oxidative properties. Uric acid could be an important biomarker for specific motor features and symptoms of fatigue in PD.