Performance of healthy persons under pain in different cognitive load tasks: An event-related potential study on experimental pain individuals
Performance of healthy persons under pain in different cognitive load tasks: An event-related potential study on experimental pain individuals
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健康人在不同认知负荷任务中疼痛下的表现：对实验性疼痛个体的事件相关电位研究
DOI：
10.1002/brb3.1713
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发表时间：
2020
影响因子：
3.1
通讯作者：
Wu Wen
中科院分区：
文献类型：
--
作者：
Wang Kangling;Cai Guiyuan;Huang Shimin;Li Yuqi;Li Rongdong;Wu Wen
本研究采用脑电图技术研究疼痛状态对不同认知负荷下的脑活动的影响。共有20名实验性疼痛受试者和20名匹配的非疼痛对照者进行了脑电图记录的认知任务。我们收集和分析的行为和事件相关电位（ERP）data.ResultsHigh认知任务表现出显着较长的反应时间和较低的准确性比低负荷的任务。实验疼痛组的准确率明显低于对照组。此外，实验组在高、低认知任务的ERP早期成分（N1、P2、N2和晚正电位早期部分的振幅）上无显著差异，而对照组在不同负荷任务之间有显著差异。此外，我们观察到延迟峰能量δ和θ振荡FZ 500-800 ms后，疼痛的人和高认知负荷tasksConclusionsInadequate早期注意调制，沿着与延迟峰能量脑振荡（δ和θ），可能是负责一个更糟糕的性能在实验疼痛组认知任务。因此，认知负荷是一个非常重要的因素。总的来说，这项研究提供了更多关于健康人群如何在神经学上处理疼痛下的认知任务的见解。
ObjectiveThis study aims to determine how brain activities underlying task with different cognitive load would be modulated by the painful state using electroencephalography.MethodsThe pain state was established by spraying capsaicin on subjects’ left inner forearm. A total of 20 experimental pain subjects and 20 matched nonpain controls underwent cognitive tasks with electroencephalogram recording. We collected and analyzed behavioral and event‐related potential (ERP) data.ResultsHigh cognitive tasks exhibited significantly longer response times and lower accuracies than low‐load tasks. The experimental pain group displayed a significantly lower accuracy than the control group. In addition, the experimental pain group showed no significance between high and low cognitive tasks in early ERP components (amplitude of N1, P2, N2, and early part of late positive potential), whereas the control group exhibited significance between different load tasks. Furthermore, we observed a delay peak energy for delta and theta oscillation in Fz 500–800 ms after the onset for pain persons and high cognitive load tasks.ConclusionsInadequate early attention modulation, along with delayed peak energy for brain oscillation (delta and theta), could be accountable for a worse performance in cognitive tasks in the experimental pain group. Thus, cognitive load is a highly considerable factor. Overall, this study offers more insights into how healthy population works with cognitive tasks under pain neurologically.