Mutagenicity of vinyl compounds in Salmonella typhimurium.
Mutagenicity of vinyl compounds in Salmonella typhimurium.
复制标题
鼠伤寒沙门氏菌中乙烯基化合物的致突变性。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
A. W. Andrews
中科院分区：
文献类型：
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作者：
W. Lijinsky;A. W. Andrews
已在5种鼠伤寒沙门氏菌菌株中检测了与致突变致癌物氯乙烯结构相关的18种化合物的致突变性。丙烯醛、丙烯醛二乙缩醛、丙烯腈、烯丙醇、烯丙基溴、巴豆醛、巴豆醇和溴乙烯对一种或多种菌株具有致突变性;丙烯醛亚硫酸氢盐、丙烯醛肟、丙烯酰胺、丙烯酸、烯丙胺、反式肉桂醛、反式肉桂酸、巴豆酸、甲基丙烯酸甲酯和乙酸乙烯酯无致突变性。在无和有大鼠和仓鼠肝微粒体制剂（S9）活化的情况下进行致突变性试验。在平板掺入和/或液体预孵育试验中检测所有化合物，但溴乙烯除外，溴乙烯作为气体进行检测。
Eighteen compounds structurally related to the mutagenic carcinogen vinyl chloride have been tested for mutagenicity in five strains of Salmonella typhimurium. Acrolein, acrolein diethylacetal, acrylonitrile, allyl alcohol, allyl bromide, crotonaldehyde, crotyl alcohol, and vinyl bromide were mutagenic with one or more strains; acrolein bisulfite, acrolein oxime, acrylamide, acrylic acid, allylamine, trans-cinnamaldehyde, trans-cinnamic acid, crotonic acid, methyl methacrylate, and vinyl acetate were not mutagenic. The mutagenicity tests were performed both without and with activation by rat and hamster liver microsomal preparations (S9). All compounds were tested in the plate incorporation and/or liquid preincubation tests except vinyl bromide, which was tested as a gas.