Elevated pulse wave velocity increases the odds of coronary calcification in overweight postmenopausal women.
Elevated pulse wave velocity increases the odds of coronary calcification in overweight postmenopausal women.
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DOI：
10.1016/j.amjhyper.2006.11.006
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发表时间：
2007-05
影响因子：
3.2
通讯作者：
Lakshmi Venkitachalam;R. Mackey;K. Sutton-Tyrrell;Ami S. Patel;M. Boraz;L. Simkin-Silverman;L. Kuller-L.-Kul
中科院分区：
文献类型：
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作者：
Lakshmi Venkitachalam;R. Mackey;K. Sutton-Tyrrell;Ami S. Patel;M. Boraz;L. Simkin-Silverman;L. Kuller-L.-Kul
背景：主动脉僵硬度，采用颈动脉-股动脉脉搏波传导速度（cfPWV）评估，可预测全因和心血管死亡率。臂踝脉搏波速度指数（baPVI）是一种使用自动系统获得的动脉僵硬度的较新测量方法。我们的目的是评估这些措施之间的关联动脉硬度和冠状动脉钙化（CAC），超重/肥胖的绝经后妇女，没有明显的心血管疾病methodsCAC进行了评估，使用电子束断层扫描在504绝经后妇女，年龄52至62岁（88.2%白色），平均体重指数（BMI）30.8公斤/平方米。CAC评分分析为CAC >0和CAC >100与CAC = 0或ln（CAC + 1）. ResultscfPWV在476名妇女中可用（平均[SD]：900（255）cm/sec），baPVI在441名妇女中可用（平均[SD]：1434（231）cm/sec）。任何CAC（CAC >0）存在于约51%的队列中。高cfPWV（RR = 1.5、1.6和1.7，四分位数2、3和4v 1）和baPVI（RR = 2.9、3.7。四分位数2、3和4v 1为4.0）与钙化的存在相关（CAC >0）。在校正年龄、收缩压、平均腰围、BMI、空腹血糖、胰岛素、血脂、激素替代治疗和吸烟状况后，这种相关性减弱，但仅对baPVI保持显著性。cfPWV（RR = 5.3）和baPVI（RR = 7.8）的最高四分位数显示严重钙化（CAC >100）的高几率，这些相关性在多变量分析中仍然显著。Am J Hypertens 2007;20：469-475 © 2007 American Journal of Hypertension，Ltd.
BackgroundAortic stiffness, assessed using carotid–femoral pulse wave velocity (cfPWV), predicts all-cause and cardiovascular mortality. Brachial–ankle pulse wave velocity index (baPVI) is a newer measure of arterial stiffness obtained using an automated system. Our aim is to evaluate the association between both these measures of arterial stiffness and coronary calcification (CAC), in overweight/obese postmenopausal women, without apparent cardiovascular disease.MethodsThe CAC was assessed using electron beam tomography in 504 postmenopausal women, aged 52 to 62 years (88.2% white) with mean body mass index (BMI) 30.8 kg/m2. The CAC scores were analyzed as CAC >0 and CAC >100 versus CAC = 0, or as ln (CAC + 1).ResultsThe cfPWV was available in 476 women (mean [SD]: 900 (255) cm/sec) and baPVI was available in 441 women (mean [SD]: 1434 (231) cm/sec. Any CAC (CAC >0) was present in approximately 51% of the cohort. Both high cfPWV (RR = 1.5, 1.6, and 1.7 for quartiles 2, 3, and 4v1) and baPVI (RR = 2.9, 3.7. and 4.0 for quartiles 2, 3, and 4v1) were associated with the presence of calcification (CAC >0). The association was attenuated but remained significant only for baPVI after adjusting for age, systolic blood pressure, average waist circumference, BMI, fasting glucose, insulin, lipids, hormone replacement therapy, and smoking status. High odds of severe calcification (CAC >100) was seen with the highest quartile of the cfPWV (RR = 5.3) and baPVI (RR = 7.8), and these associations remained significant in multivariable analysis.ConclusionsBoth cfPWV and baPVI are associated with presence and severity of coronary calcification in overweight postmenopausal women. Am J Hypertens 2007;20: 469–475 © 2007 American Journal of Hypertension, Ltd.