GATA factors as key regulatory molecules in the development of Drosophila endoderm
GATA factors as key regulatory molecules in the development of Drosophila endoderm
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DOI：
10.1111/j.1440-169x.2005.00836.x
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发表时间：
2005-12
期刊：
影响因子：
4.6
通讯作者：
R. Murakami;T. Okumura;H. Uchiyama
中科院分区：
文献类型：
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作者：
R. Murakami;T. Okumura;H. Uchiyama
GATA因子在内胚层发育中的重要作用已在各种动物中得到报道。果蝇GATA因子基因Serpent(SRP，dGATAb，ABF)在预期的内胚层中表达，SRP活性的丧失会导致预期的内胚层向外胚层前部和后肠转化，表明SRP基因是决定内胚层发育命运的选择基因。虽然SRP只在早期阶段在内胚层表达，但它激活了随后的GATA因子基因dGATAe，后者在整个生命过程中继续在内胚层特异表达。DGATAe激活分化的内胚层中肠中的各种功能基因。在秀丽线虫中也有类似的调控模式，其中一对GATA基因END-1/3决定内胚层的命运，下游的一对GATA基因ELT-2/7激活分化内胚层中的基因。自然界中GATA基因的功能同源性显然可以延伸到脊椎动物，因为线虫和果蝇的内胚层GATA基因诱导了非洲爪哇外胚层的内胚层发育。这些发现强烈暗示GATA因子在原口和后口的内胚层中的作用在进化上是保守的。
Essential roles for GATA factors in the development of endoderm have been reported in various animals. A Drosophila GATA factor gene, serpent (srp, dGATAb, ABF), is expressed in the prospective endoderm, and loss of srp activity causes transformation of the prospective endoderm into ectodermal foregut and hindgut, indicating that srp acts as a selector gene to specify the developmental fate of the endoderm. While srp is expressed in the endoderm only during early stages, it activates a subsequent GATA factor gene, dGATAe, and the latter continues to be expressed specifically in the endoderm throughout life. dGATAe activates various functional genes in the differentiated endodermal midgut. An analogous mode of regulation has been reported in Caenorhabditis elegans, in which a pair of GATA genes, end‐1/3, specifies endodermal fate, and a downstream pair of GATA genes, elt‐2/7, activates genes in the differentiated endoderm. Functional homology of GATA genes in nature is apparently extendable to vertebrates, because endodermal GATA genes of C. elegans and Drosophila induce endoderm development in Xenopus ectoderm. These findings strongly imply evolutionary conservation of the roles of GATA factors in the endoderm across the protostomes and the deuterostomes.