Effects of human immunodeficiency virus on the cellular immune response to Epstein-Barr virus in homosexual men: characterization of the cytotoxic response and lymphokine production.
Effects of human immunodeficiency virus on the cellular immune response to Epstein-Barr virus in homosexual men: characterization of the cytotoxic response and lymphokine production.
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DOI：
10.1093/infdis/155.5.877
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发表时间：
1987-05
期刊：
影响因子：
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通讯作者：
R. Blumberg;T. Paradis;R. Byington;W. Henle;M. S. Hirscb;R. Schooley
中科院分区：
文献类型：
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作者：
R. Blumberg;T. Paradis;R. Byington;W. Henle;M. S. Hirscb;R. Schooley
我们调查了患有艾滋病或有艾滋病风险的同性恋男性的 Epstein-Barr 病毒 (EBV) 特异性 T 细胞反应。我们研究了健康的实验室工作人员、健康的同性恋男性以及患有艾滋病相关综合症或艾滋病的患者。随着人类免疫缺陷病毒（HIV）感染程度的增加，细胞毒性活性、T4淋巴细胞的绝对数量和白细胞介素-2（IL-2）的产生减少，而Ia+淋巴细胞的相对数量增加。细胞毒活性与 T4 淋巴细胞数量（r = .56，P 小于 0.001）和 IL-2 产生量（r = .47，P 小于 0.01）呈正相关，但与干扰素产生无关。重组IL-2（而非γ干扰素）可以将早期HIV感染患者的细胞毒性T细胞活性恢复到控制水平。 EBV 特异性血清学研究与 T 淋巴细胞研究并行。在进行性 HIV 感染中观察到的 EBV 活性增加可能与 T4 淋巴细胞亚群自身反应群体的减少有关，并且可能适合 IL-2 重建。
We investigated Epstein-Barr virus (EBV)-specific T cell responses in homosexual men with, and at risk for, AIDS. We studied healthy laboratory workers, healthy homosexual men, and patients with AIDS-related complex or AIDS. The cytotoxic activity, absolute number of T4 lymphocytes, and interleukin-2 (IL-2) production decreased, whereas the relative number of Ia+ lymphocytes increased with the extent of infection with the human immunodeficiency virus (HIV). Cytotoxic activity correlated positively with the number of T4 lymphocytes (r = .56, P less than .001) and the amount of IL-2 produced (r = .47, P less than .01) but not with interferon production. Recombinant IL-2, but not gamma interferon, could restore cytotoxic T cell activity to control levels in patients with early HIV infection. EBV-specific serological studies paralleled the T lymphocyte investigations. The increased EBV activity observed in progressive HIV infection may be related to a diminution in the auto-reactive population of the T4 lymphocyte subset and may be amenable to IL-2 reconstitution.