The Comparative Toxicogenomics Database (CTD): A resource for comparative toxicological studies
The Comparative Toxicogenomics Database (CTD): A resource for comparative toxicological studies
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DOI：
10.1002/jez.a.307
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发表时间：
2006-09-01
影响因子：
2.8
通讯作者：
Boyer, J. L.
中科院分区：
文献类型：
--
作者：
Mattingly, C. J.;Rosenstein, M. C.;Boyer, J. L.
大多数慢性疾病的病因学涉及环境因素与调节重要生物过程的基因之间的相互作用（奥登and Wilson，2000. Nat Rev Genet 1（2）：149-153）。我们正在开发公开的比较毒理基因组学数据库（CTD），以促进对环境化学品对人类健康影响的了解。CTD确定化学品和基因之间的相互作用，并促进这些基因的跨物种比较研究。使用不同的动物模型和跨物种比较序列研究对于理解基本生理机制以及基因和蛋白质功能至关重要。同样，这些方法将是有价值的探索环境化学品的分子作用机制和差异易感性的遗传基础。
The etiology of most chronic diseases involves interactions between environmental factors and genes that modulate important biological processes (Olden and Wilson, 2000. Nat Rev Genet 1(2):149-153). We are developing the publicly available Comparative Toxicogenomics Database (CTD) to promote understanding about the effects of environmental chemicals on human health. CTD identifies interactions between chemicals and genes and facilitates cross-species comparative studies of these genes. The use of diverse animal models and cross-species comparative sequence studies has been critical for understanding basic physiological mechanisms and gene and protein functions. Similarly, these approaches will be valuable for exploring the molecular mechanisms of action of environmental chemicals and the genetic basis of differential susceptibility.