Efficiency of Go/No-Go Task Performance Implemented in the Left Hemisphere
Efficiency of Go/No-Go Task Performance Implemented in the Left Hemisphere
复制标题
DOI：
10.1523/jneurosci.0540-12.2012
复制
发表时间：
2012-06-27
影响因子：
5.3
通讯作者：
Konishi, Seiki
中科院分区：
文献类型：
--
作者：
Hirose, Satoshi;Chikazoe, Junichi;Konishi, Seiki
众所周知，反应抑制的效率因人而异，但实现这种效率的神经机制却鲜为人知。在本研究中，我们设计了一个评价在走/不走任务中反应抑制效率的指标，并探讨了反应抑制效率的神经相关机制。在围棋试验（go- rt）中以较短的反应时间和较高的正确率（Nogo-PC）执行go/no-go任务的人类受试者被认为具有更有效地进行反应抑制的能力。为了量化效率，我们将效率指数定义为在相同的Go-RT下，每个受试者与正常效率受试者之间的Nogo-PC的差异。跨主体相关分析显示，大脑左额叶和顶叶皮层多个区域的活动与效率指数呈正相关。此外，关于跨主题相关性的半球不对称测试显示左半球优势。左额叶和顶叶区域的显著相关性补充了先前使用停止信号反应时间（SSRT）的研究结果，SSRT是评估停止信号任务中反应抑制效率的一个众所周知的指标。我们的研究结果还表明，尽管众所周知，反应抑制的神经基质主要存在于右半球，但效率的神经基质主要存在于左半球。
It is well known that the efficiency of response inhibition differs from person to person, but the neural mechanism that implements the efficiency is less understood. In the present fMRI study, we devised an index to evaluate the efficiency of response inhibition in the go/no-go task, and investigated the neural correlates of the efficiency of response inhibition. The human subjects who perform the go/no-go task with a shorter reaction time in go trials (Go-RT) and with a higher percentage of correct no-go trials (Nogo-PC) are thought to have the ability to conduct response inhibition more efficiently. To quantify the efficiency, we defined an efficiency index as the difference in the Nogo-PC between each subject and an ordinarily efficient subject, under the same Go-RT. An across-subject correlation analysis revealed that the brain activity in multiple regions in the left frontal and parietal cortex positively correlated with the efficiency index. Moreover, a test of hemispheric asymmetry with regard to the across-subject correlation revealed left-hemispheric dominance. The significant correlation in the left frontal and parietal regions complements the results of previous studies that used the stop-signal reaction time (SSRT), a well known index to evaluate the efficiency of response inhibition used in the stop-signal task. Our results also indicate that, although it is well known that the neural substrates for response inhibition common in a subject group exist dominantly in the right hemisphere, the neural substrates for efficiency exist dominantly in the left hemisphere.