Molecular and functional diversity of the oxytocinase subfamily of M1 aminopeptidases
Molecular and functional diversity of the oxytocinase subfamily of M1 aminopeptidases
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M1 氨肽酶催产素酶亚家族的分子和功能多样性
DOI：
10.1093/jb/mvab009
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Ohnishi Atsushi
中科院分区：
文献类型：
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作者：
Tsujimoto Masafumi;Aoki Kazuma;Goto Yoshikuni;Ohnishi Atsushi
胎盘亮氨酸氨肽酶/胰岛素调节的氨肽酶、内质网氨肽酶1和内质网氨肽酶2是称为“催产素酶亚家族”的M1氨肽酶的不同亚家族的一部分。由于翻译起始位点的不同使用、选择性剪接和多个单核苷酸多态性，该亚家族成员显示出分子多样性。越来越明显的是，取决于它们的细胞内或细胞外位置，催产素酶亚家族的成员在维持稳态中起重要作用，包括调节血压、维持正常妊娠、保持记忆和修剪呈递给主要组织相容性复合物I类分子的抗原肽，通过在细胞中作为氨肽酶或特定功能蛋白的结合伴侣。基于它们的分子多样性和兼职蛋白质样特性，可以想象，该亚家族成员在进化过程中发挥多效性作用，成为调节稳态的重要参与者。
The placental leucine aminopeptidase/insulin-regulated aminopeptidase, endoplasmic reticulum aminopeptidase 1 and endoplasmic reticulum aminopeptidase 2 are part of a distinct subfamily of M1 aminopeptidases termed the ‘oxytocinase subfamily’. The subfamily members show molecular diversity due to differential usage of translation initiation sites, alternative splicing and multiple single nucleotide polymorphisms. It is becoming evident that, depending on their intracellular or extracellular location, members of the oxytocinase subfamily play important roles in the maintenance of homeostasis, including the regulation of blood pressure, maintenance of normal pregnancy, retention of memory and trimming of antigenic peptides presented to major histocompatibility complex class I molecules, by acting as either aminopeptidases or binding partners of specific functional proteins in the cells. Based on their molecular diversity and moonlighting protein-like properties, it is conceivable that the subfamily members exert pleiotropic effects during evolution, to become important players in the regulation of homeostasis.