Prentice award lecture 2011: removing the brakes on plasticity in the amblyopic brain.
Prentice award lecture 2011: removing the brakes on plasticity in the amblyopic brain.
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DOI：
10.1097/opx.0b013e318257a187
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Levi DM
中科院分区：
文献类型：
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作者：
Levi DM
经验依赖性可塑性与感觉功能的发展密切相关。在这个敏感期过后，发育的可塑性受到积极的限制；然而，新的研究为成人视觉系统的可塑性提供了越来越多的证据。弱视视觉系统是检查关键时期后限制功能恢复的“刹车”的一个极好的模型。虽然弱视在早期治疗时往往可以逆转，但常规治疗通常不适用于年龄较大的儿童和成年人。然而，在动物和人类中进行的新的临床和实验研究为超过临界期的神经可塑性提供了证据。结果表明，知觉学习和玩电子游戏可能会有效地改善一系列视觉表现指标，重要的是，这种改善可能会转化为更好的视觉敏锐度和立体视觉。这些发现以及新的临床试验结果表明，现在可能是时候重新考虑我们对弱视神经可塑性的看法了。
Experience-dependent plasticity is closely linked with the development of sensory function. Beyond this sensitive period, developmental plasticity is actively limited; however, new studies provide growing evidence for plasticity in the adult visual system. The amblyopic visual system is an excellent model for examining the “brakes” that limit recovery of function beyond the critical period. While amblyopia can often be reversed when treated early, conventional treatment is generally not undertaken in older children and adults. However new clinical and experimental studies in both animals and humans provide evidence for neural plasticity beyond the critical period. The results suggest that perceptual learning and video game play may be effective in improving a range of visual performance measures and importantly the improvements may transfer to better visual acuity and stereopsis. These findings, along with the results of new clinical trials, suggest that it might be time to re-consider our notions about neural plasticity in amblyopia.