Chromosomal passengers and the (aurora) ABCs of mitosis
Chromosomal passengers and the (aurora) ABCs of mitosis
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DOI：
10.1016/s0962-8924(00)01880-8
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发表时间：
2001-02-01
影响因子：
19
通讯作者：
Earnshaw, WC
中科院分区：
文献类型：
--
作者：
Adams, RR;Carmena, M;Earnshaw, WC
染色体乘客蛋白是在有丝分裂过程中从着丝粒移动到纺锤体中间区的蛋白质。最近的实验表明，乘客内着丝粒蛋白（INCENP）和极光-B激酶是在一个大分子复合物，也可能包含第三个乘客，生存素。染色体过客复合体在整个有丝分裂过程中染色体凝聚和分离，以及在有丝分裂结束时胞质分裂的完成中发挥作用。
Chromosomal passengers are proteins that move from centromeres to the spindle midzone during mitosis. Recent experiments show that the passengers inner centromere protein (INCENP) and aurora-B kinase are in a macromolecular complex that might also contain a third passenger, survivin. The chromosomal passenger complex functions throughout mitosis in chromosome condensation and segregation, and at the end of mitosis, in the completion of cytokinesis.