VITAMIN-B12 ABSORPTION FROM FISH
VITAMIN-B12 ABSORPTION FROM FISH
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DOI：
10.3181/00379727-167-41201
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发表时间：
1981-01-01
影响因子：
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通讯作者：
ECONOMON, P
中科院分区：
文献类型：
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作者：
DOSCHERHOLMEN, A;MCMAHON, J;ECONOMON, P
研究了鱼类对氰钴胺素的同化作用。给虹鳟注射57co -维生素B12, 2-3周后处死。放射性物质均匀地分布在肌肉群中。与鸟类和哺乳动物的研究结果相反，肝脏的放射性含量平均低于肾脏、头部、皮肤和肌肉。3名健康受试者按50 ~ 300克的分量摄入放射性标记鱼，并通过粪便排泄法测量吸收情况。从平均2.07亩。维生素B12（50克鱼），4.05 .mu。G (100g), 9.2 .mu。G (200 G)， 13.3亩。G （300 G）对钴胺素的同化平均为0.87、1.55、3.90和3.98 .mu。分别g。在2名受试者中，吸收量达到了上限，而在1名受试者中，吸收量仍在攀升。健康受试者和血清维生素B12水平较低的患者分别食用100克鱼进行标准尿排泄试验，结果显示，在食用鱼和恶性贫血患者服用结晶放射性氰钴胺素后，其吸收值非常低。单纯性胃酸缺血症患者和部分胃切除术患者体内钴胺素的吸收低于正常水平，而晶体放射性- b12的吸收正常。
The assimilation of cyanocobalamin from fish was studied. Rainbow trout were injected with 57Co-vitamin B12 and sacrificed 2-3 wk later. The radioactivity was evenly distributed in the muscle mass. In contrast to findings in birds and mammals, the liver contained on the average less radioactivity than did the kidneys, head, skin and muscle mass. The radiolabeled fish was ingested by 3 healthy subjects in 50- to 300-g portions and the absorption measured by the stool excretion method. From an average of 2.07 .mu.g of vitamin B12 (50 g of fish), 4.05 .mu.g (100 g), 9.2 .mu.g (200 g) and 13.3 .mu.g (300 g) the assimilation of cobalamin averaged 0.87, 1.55, 3.90 and 3.98 .mu.g, respectively. In 2 of the subjects, an upper limit of absorption was reached, while in one it was still climbing. A standard urinary excretion test using 100 g of fish, eaten by healthy subjects and by patients who presented with low serum vitamin B12 levels, showed very low absorption values after the fish and after the crystalline radiocyanocobalamin in patients with pernicious anemia. Subnormal assimilation of cobalamin from the fish with normal absorption of crystalline radio-B12 was noted in subjects with simple gastric achlorhydria and in patients who had undergone partial gastrectomy.