Cortical locations of maximal spindle activity: magnetoencephalography (MEG) study
Cortical locations of maximal spindle activity: magnetoencephalography (MEG) study
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DOI：
10.1111/j.1365-2869.2008.00717.x
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发表时间：
2009-06-01
影响因子：
4.4
通讯作者：
Drake, Christopher L.
中科院分区：
文献类型：
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作者：
Gumenyuk, Valentina;Roth, Thomas;Drake, Christopher L.
本研究旨在利用脑磁图（MEG）确定健康受试者在短暂的晨间小睡期间与睡眠阶段2的最大纺锤体活动相关的主要皮层区域。八名志愿者（平均年龄：26.1 +/- 8.7，六名女性）都是右利手，没有任何医学精神或睡眠障碍进行了研究。使用全头148通道MEG和常规多导睡眠图导联（EEG; C3、C4、O 1和O2头皮电极以及EOG、EMG和ECG电极）进行数据收集。睡眠MEG/EEG纺锤波视觉识别在15分钟的阶段2睡眠的每个参与者。使用独立成分分析和叠加在个体MRI上的电流源密度技术的组合来计算对应于每个纺锤体的脑活动的分布。纺锤体激活的绝对最大值位于额叶、颞叶和顶叶。然而，最常见的皮质区域的最大源纺锤体活动的中央前和/或中央后区在所有的个人。本研究表明，最大的纺锤体活动本地化到这两个区域可能代表一个单一的事件，两种类型的纺锤体频率：慢（在12 Hz）和快（在14 Hz）在全球丘脑皮质的连贯性。
The aim of this study was to determine the main cortical regions related to maximal spindle activity of sleep stage 2 in healthy individual subjects during a brief morning nap using magnetoencephalography (MEG). Eight volunteers (mean age: 26.1 +/- 8.7, six women) all right handed, free of any medical psychiatric or sleep disorders were studied. Whole-head 148-channel MEG and a conventional polysomnography montage (EEG; C3, C4, O1 and O2 scalp electrodes and EOG, EMG and ECG electrodes) were used for data collection. Sleep MEG/EEG spindles were visually identified during 15 min of stage 2 sleep for each participant. The distribution of brain activity corresponding to each spindle was calculated using a combination of independent component analysis and a current source density technique superimposed upon individual MRIs. The absolute maximum of spindle activation was localized to frontal, temporal and parietal lobes. However, the most common cortical regions for maximal source spindle activity were precentral and/or postcentral areas across all individuals. The present study suggests that maximal spindle activity localized to these two regions may represent a single event for two types of spindle frequency: slow (at 12 Hz) and fast (at 14 Hz) within global thalamocortical coherence.