Meta-analysis of associations between childhood adversity and hippocampus and amygdala volume in non-clinical and general population samples.
Meta-analysis of associations between childhood adversity and hippocampus and amygdala volume in non-clinical and general population samples.
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DOI：
10.1016/j.nicl.2017.02.016
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Kempton MJ
中科院分区：
文献类型：
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作者：
Calem M;Bromis K;McGuire P;Morgan C;Kempton MJ
对精神病学人群的研究已经报告了童年逆境和与压力相关的大脑结构体积之间的联系。这项荟萃分析在非临床样本中调查了这些相关性，因此独立于严重精神健康困难及其治疗的影响。在MEDLINE数据库中搜索磁共振成像研究，以测量有和没有童年逆境的成年人的大脑结构。使用随机效应荟萃分析收集了15篇报告海马体和/或杏仁核体积的合格论文(1781名参与者)。童年有逆境的人海马体体积较小(对冲g=−=0.15，p=0.010)。在对性别进行控制后，这种差异变得不那么明显(对冲g=−=0.12，p=0.124)。这种联系的不同取决于研究是否包括有一些精神病理学的参与者，尽管这可能是因为这些研究检查的逆境类型的不同。没有强有力的证据表明杏仁核体积有任何差异。在那些没有明显心理健康问题的人中，童年的逆境可能只会对与压力相关的大脑结构产生轻微的影响。在患有童年逆境的非临床人群中发现的海马体体积减少，这种影响没有在精神疾病人群中发现的明显。有一些证据表明，性别造成了混淆。需要进一步研究不同形式的逆境对神经解剖学的影响。
Studies of psychiatric populations have reported associations between childhood adversity and volumes of stress-related brain structures. This meta-analysis investigated these associations in non-clinical samples and therefore independent of the effects of severe mental health difficulties and their treatment. The MEDLINE database was searched for magnetic resonance imaging studies measuring brain structure in adults with and without childhood adversity. Fifteen eligible papers (1781 participants) reporting hippocampal volumes and/or amygdala volumes were pooled using a random effects meta-analysis. Those with childhood adversity had lower hippocampus volumes (hedges g = − 0.15, p = 0.010). Controlling for gender, this difference became less evident (hedges g = − 0.12, p = 0.124). This association differed depending on whether studies included participants with some psychopathology, though this may be due to differences in the type of adversity these studies examined. There was no strong evidence of any differences in amygdala volume. Childhood adversity may have only a modest impact on stress-related brain structures in those without significant mental health difficulties. Reduced hippocampal volume found in non-clinical people with childhood adversity This effect was less marked than those found in psychiatric populations. There was some evidence for confounding by gender. Further studies needed on impact of different forms of adversity on neuroanatomy.