Acid hydrolase activities and lysosomal integrity in liver biopsies from patients with iron overload.
Acid hydrolase activities and lysosomal integrity in liver biopsies from patients with iron overload.
复制标题
铁超载患者肝活检中的酸性水解酶活性和溶酶体完整性。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
C. Seymour
中科院分区：
文献类型：
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作者：
T. Peters;C. Seymour
1.对正常人、原发性和继发性血色素沉着症患者肝活检组织中的铁、酸性磷酸酶和N-乙酰-β-氨基葡萄糖苷酶进行了检测。2.铁超载患者肝组织中溶酶体酶活性显著高于其他患者组。3.潜伏期和沉降性N-乙酰-β-氨基葡萄糖苷酶测定表明，铁超负荷患者肝脏溶酶体明显比正常对照组脆弱。4.在各种慢性肝病患者的活检中，溶酶体完整性基本上是正常的。5.铁积累损伤溶酶体膜，释放酸性水解酶进入细胞质，从而启动细胞损伤。
1. Iron, acid phosphatase and N-acetyl-beta-glucosaminidase were assayed in liver biopsies from control subjects and patients with primary and secondary haemochromatosis. 2. The activities of the lysosomal enzymes were significantly higher in liver biopsies from patients with iron overload than in those from other patient groups. 3. Lysosomes from the livers of patients with iron overload were strikingly more fragile than those of control subjects as demonstrated by assays of latent and sedimentable N-acetyl-beta-glucosaminidase. 4. Lysosomal integrity was essentially normal in biopsies from patients with a wide variety of chronic liver diseases. 5. It is suggested that iron accumulation damages lysosomal membrane, releasing acid hydrolases into the cytoplasm and thus initiating cell damage.