The effect of manganous chloride and tetrodotoxin on Limulus lateral eye retinular cells.
The effect of manganous chloride and tetrodotoxin on Limulus lateral eye retinular cells.
复制标题
氯化锰和河豚毒素对鲎外侧眼网状细胞的影响。
DOI：
10.1016/0042-6989(73)90232-0
复制
发表时间：
1973
期刊：
影响因子：
1.8
通讯作者：
C. Méndez
中科院分区：
文献类型：
--
作者：
V. J. Wulff;C. Méndez
海水中8-14 mM氯化锰对鲎侧眼视网膜细胞的各项参数均有影响;（1）膜电位降低，（2）感受器电位潜伏期延长，（3）有效输入电阻增加，（4）感受器电位C1、C2分量幅值降低，C3分量幅值增加，（5）受体电位的反转电位增加;（6）受体电位的反转幅度明显降低。有人提出，锰离子发挥两种作用：一个是减少Ca ~（2+）内流，另一个是减少小网膜细胞膜的通透性，河豚毒素可逆地阻断偏心细胞锋电位，但没有观察到的小网膜细胞测量的这些属性的影响。
Manganese chloride dissolved in sea water at concentrations of 8–14 mmaffected all of the measured parameters ofLimuluslateral eye retinular cells;(1) the membrane potential decreased,(2) the latent period of the receptor potential increased,(3) the effective input resistance increased,(4) the magnitudes of componentsC1andC2of the receptor potential decreased but that of componentC3increased,(5) the reversal potential of the receptor potential increased and(6) the magnitude of the reversed receptor potential was markedly reduced. It is proposed that manganese ions exert two effects: one is the reduction of Ca2+influx and the other is a reduction in permeability of the retinular cell membrane.Tetrodotoxin reversibly blocked eccentric cell spike potentials but had no observable effects on those properties of retinular cells that were measured.