Unified description of regeneration by coupled dynamical systems theory: Intercalary/segmented regeneration in insect legs
Unified description of regeneration by coupled dynamical systems theory: Intercalary/segmented regeneration in insect legs
复制标题
耦合动力系统理论对再生的统一描述：昆虫腿部的闰/分段再生
作者：
H. Yoshida;K. Kaneko
再生现象在自然界中普遍存在，并在各种实验中进行了研究。位置信息和反馈回路层次理论是用来解释再生中的有序规则的理论;然而，一些再生现象违反了从它们导出的规则。特别是，具有相同值/层次的嫁接连接树桩有时会导致一个额外的分段部分，称为分段再生。为了对所有昆虫腿再生现象进行统一描述，我们提出了一种不假设位置信息的再生理论机制，通过使用由化学浓度的细胞内反应动力学，细胞间相互作用和细胞数量增加组成的模型。作为一个正常的发育过程，出现了从多能细胞的连续分化，如从具有细胞内混沌动力学的细胞向具有振荡或定点动力学的细胞的转变所描述的。通过分配混乱和非混乱的细胞类型，而不是位置信息，插，分割，和跗骨再生的相应位置的解释连贯。通过将多能性分配给混沌动力学，获得了再生的统一描述，对新的实验具有一定的预测价值。发展动力学238：1974-1983，2009年。© 2009 Wiley利斯公司
Regeneration phenomena are ubiquitous in nature and are studied in a variety of experiments. Positional information and feedback‐loop hierarchy are theories that have been proposed to explain ordering rules in regeneration; however, some regeneration phenomena violate the rules derived from them. In particular, grafted junction stumps with the same value/hierarchy sometimes lead to one extra segmented portion, termed segmented regeneration. To present a unified description of all insect leg regeneration phenomena, we propose a theoretical mechanism for regeneration without postulating positional information, by using a model that consists of intracellular reaction dynamics of chemical concentrations, cell‐to‐cell interactions, and an increase in cell number. As a normal developmental process, successive differentiation from pluripotent cells appears, as described by transition from cells with intracellular chaotic dynamics to those with oscillatory or fixed‐point dynamics. By assigning chaotic and nonchaotic cell types to corresponding positions instead of positional information, intercalary, segmented, and tarsus regeneration are explained coherently. With this assignment of pluripotency to chaotic dynamics, a unified description of regeneration is obtained with some predictive value for new experiments. Developmental Dynamics 238:1974–1983, 2009. © 2009 Wiley‐Liss, Inc.