Short-term course of neuropsychological abilities in middle-aged and older adults with bipolar disorder
Short-term course of neuropsychological abilities in middle-aged and older adults with bipolar disorder
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DOI：
10.1111/j.1399-5618.2008.00601.x
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发表时间：
2008-09-01
影响因子：
5.4
通讯作者：
Jeste, Dilip V.
中科院分区：
文献类型：
--
作者：
Depp, Colin A.;Savla, Gauri N.;Jeste, Dilip V.
目的：关于双相情感障碍的神经认知的纵向研究很少，而且双相情感障碍后期认知缺陷的短期病程尚不清楚。我们对35名社区门诊双相情感障碍患者进行了一系列神经认知测试，在基线后1-3年重复进行（平均年龄= 58岁），并将他们在认知功能综合测量方面的表现与人口统计学匹配的正常对照受试者样本进行比较（NC; n = 35）和精神分裂症患者（n = 35）。使用回归分析，我们检查了基线表现的组间差异，随时间变化的轨迹，以及随时间变化的表现。在双相组内，我们研究了基线的严重程度和精神症状的严重程度的变化对个体内的变化在neurocognitive performance.Results：在基线的影响，双相情感障碍组不同的整体神经认知功能的NC，但没有显着差异精神分裂症组。双相组在时间点之间的平均变化轨迹与NC或精神分裂症组没有差异，但双相患者随时间的个体内变异性高于NC或精神分裂症组。在双相组，神经认知功能的变化是不相关的基线或精神症状severity.Conclusions的变化：中老年社区居住的成年人与双相情感障碍有更大的短期变异水平的神经认知功能相对于NC或精神分裂症的人。双相情感障碍认知功能障碍的发展过程和危险因素应在未来的纵向研究中进行审查。
Objectives: There are few longitudinal studies of neurocognition in bipolar disorder, and the short-term course of cognitive deficits in later-life bipolar disorder is unknown.Methods: We administered a battery of neurocognitive tests, repeated 1-3 years after baseline, to 35 community-dwelling outpatients with bipolar disorder (mean age = 58), and compared their performance on a composite measure of cognitive functioning to that of demographically matched samples of normal comparison subjects (NCs; n = 35) and patients with schizophrenia (n = 35). Using regression analyses, we examined group differences in baseline performance, trajectory of change over time, and variability in performance across time. Within the bipolar group, we examined the impact of baseline severity and change in severity of psychiatric symptoms on intra-individual change in neurocognitive performance.Results: At baseline, the group with bipolar disorder differed in overall neurocognitive functioning from the NCs, but did not differ significantly from the schizophrenia group. The bipolar group did not differ from the NCs or schizophrenia group in the mean trajectory of change between time-points, but the bipolar patients showed more intra-individual variability over time than the NCs or schizophrenia group. In the bipolar group, change in neurocognitive function was not related to baseline or change in psychiatric symptom severity.Conclusions: Middle-aged and older community-dwelling adults with bipolar disorder have greater short-term variability in level of neurocognitive functioning relative to NCs or people with schizophrenia. The developmental course of and risk factors for cognitive deficits in bipolar disorder should be examined in future longitudinal studies.