Estrogen receptors α and β mediate different aspects of the facilitatory effects of female cues on male risk taking
Estrogen receptors α and β mediate different aspects of the facilitatory effects of female cues on male risk taking
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DOI：
10.1016/j.psyneuen.2008.02.003
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发表时间：
2008-06-01
影响因子：
3.7
通讯作者：
Ogawa, Sonoko
中科院分区：
文献类型：
--
作者：
Kavaliers, Martin;Devidze, Nino;Ogawa, Sonoko
择偶风险和决策受到与性有关的暗示的影响，男性在女性和/或她们的暗示面前做出更差和更冒险的决定。在非人类物种中，雌性的暗示也会增加交配的风险，减少它们对捕食者威胁的反应。由于雌激素受体α和β（ER α和ER β）参与社会和性反应的调解，我们研究了它们在确定女性相关线索对配偶冒险行为的影响方面的作用。我们研究了在ER α和ER β野生型（α ERWT，β ERWT）和基因缺失（敲除，α ERKO，β ERKO）交配小鼠中，短暂预暴露于新的或熟悉的发情期雌性气味对避免和厌恶捕食者威胁（猫气味）的影响。将α ERWT和α ERWT配偶暴露于新的但不是熟悉的发情雌性小鼠的气味导致冒险增加，其中配偶对猫气味的回避和镇痛反应减少。相比之下，α ERKO交配小鼠在冒险方面没有表现出任何变化，而β ERKO交配小鼠虽然表现出更大的冒险，但并没有区分新的和熟悉的雌性，在暴露于新的或熟悉的雌性气味后，对猫气味的回避反应也同样减少。这些研究结果表明，ER α基因与性机制（对发情女性的反应）相关，ER β和ER α基因与女性线索对配偶冒险行为影响的社会机制（对新女性的识别）相关。(C)2008爱思唯尔有限公司保留所有权利。
Mate risk taking and decision making are affected by sex-related cues, with men making poorer and riskier decisions in the presence of females and, or their cues. In non-human species, female cues can also increase mate risk taking, reducing their responses to predator threat. As estrogen receptors alpha and beta (ER alpha and ER beta) are involved in the mediation of social and sexual responses, we investigated their roles in determining the effects of female-associated cues on mate risk taking. We examined the effects of brief pre-exposure to the odors of either a novel or familiar estrous female on the avoidance of, and aversive responses to, predator threat (cat odor) in ER alpha and ER beta wild type (alpha ERWT, beta ERWT) and gene-deleted (knockout, alpha ERKO, beta ERKO) mate mice. Exposure of alpha ERWT and alpha ERWT mates to the odors of a novel, but not a familiar, estrous female mouse resulted in enhanced risk taking with the mates displaying reduced avoidance of, and analgesic responses to, cat odor. In contrast, alpha ERKO mate mice failed to show any changes in risk taking, while beta ERKO mates, although displaying greater risk taking, did not distinguish between novel and familiar females, displaying similarly reduced avoidance responses to cat odor after exposure to either a novel or familiar female odor. These findings indicate that the gene for ER alpha is associated with the sexual mechanisms (response to estrous female) and the genes for ER beta and ER alpha with the social (recognition of novel female) mechanisms underlying the effects of female cues on mate risk taking. (C) 2008 Elsevier Ltd. All rights reserved.