The evaluation of cognitive functions with P300 test for chronic obstructive pulmonary disease patients in attack and stable period
The evaluation of cognitive functions with P300 test for chronic obstructive pulmonary disease patients in attack and stable period
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DOI：
10.1016/j.clineuro.2007.03.013
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发表时间：
2007-09-01
影响因子：
1.9
通讯作者：
Muz, Mehmet Hamdi
中科院分区：
文献类型：
--
作者：
Kirkil, Gamze;Tug, Tuncer;Muz, Mehmet Hamdi
目的：慢性阻塞性肺疾病（COPD）中的缺氧导致脑灌注减少和某些认知能力受损。为探讨慢性阻塞性肺疾病（COPD）患者发作期和稳定期动脉血气分析（阿坝）、肺功能（PFT）指标与认知功能的关系，对30例稳定期、30例发作期COPD患者和17例健康对照者进行阿坝、PFT、P300测试。COPD组与对照组比较，对照组P300潜伏期明显缩短（P < 0.001），而COPD组间P300潜伏期无明显差异（P > 0.05）。两组COPD患者P300波幅均低于对照组，但差异无统计学意义发作组与对照组比较，动脉血氧分压（PaO 2）、动脉血氧饱和度（SaO 2）、第1秒用力呼气量（FEV 1）、FEV 1/用力肺活量（FVC）均升高P300潜伏期缩短（P < 0.001）P300潜伏期与PaO 2显著相关（P < 0.05（r=-0.557，p < 0.001）、SaO 2（r=-0.424，p < 0.001）、FEV 1（r=-0.441，p < 0.001）、FEV 1/FVC（r=-0.477，p < 0.001）和年龄（r= 0.329，p < 0.05）。P300波幅仅与PaO 2相关（r= 0.236，p < 0.05）。P300测验可作为认知功能障碍的客观指标。(c)2007 Elsevier B. V.保留所有权利。
Objectives: Hypoxia, in chronic obstructive pulmonary disease (COPD), leads to a decrease in cerebral perfusion and an impairment of some cognitive abilities. We aimed to investigate the relation between arterial blood gas analysis (ABA) and pulmonary function test (PFT) parameters with cognitive function of COPD patients during attack and stable period.Patients and methods: ABA, PFT, P300 tests of 30 patients in stabilized period and 30 patients in attack, and 17 healthy controls were evaluated.Results: When both COPD groups and controls were compared, it was seen that latency of P300 was shorter in the control group (p < 0.001), but there was no difference between COPD groups (p > 0.05). P300 amplitude measures were lower in both COPD groups than control group, but it was not statistically significant (p > 0.05).When we compared the measures of attack group, we saw that arterial oxygen tension (PaO2), arterial oxygen saturation (SaO(2)), forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC) values increased (p < 0.001), and P300 latency shortened (p < 0.05) in attack group during stable period.P300 latency correlated significantly with PaO2 (r=-0.557, p < 0.001), SaO(2) (r=-0.424, p < 0.001), FEV1 (r=-0.441, p < 0.001), FEV1/FVC (r=-0.477, p < 0.001) values, and age (r=0.329,p < 0.05). P300 amplitude is only correlated with PaO2 (r=0.236,p < 0.05).Conclusion: Longer latency of P300 appears to be an expected sequel of COPD. P300 test can be considered as a potential objective marker of cognitive impairment. (c) 2007 Elsevier B.V. All rights reserved.