Dual-modality breast tomosynthesis.
Dual-modality breast tomosynthesis.
复制标题
双模态乳房断层合成。
DOI：
10.1148/radiol.09091160
复制
发表时间：
2010
期刊：
影响因子：
19.7
通讯作者：
Majewski,Stanislaw
中科院分区：
文献类型：
--
作者：
Williams,MarkB;Judy,PatriciaG;Gunn,Spencer;Majewski,Stanislaw
目的评价双模断层合成（DMT）和99m sestamibi锝混合扫描仪提供三维解剖和功能图像的临床性能。材料和方法在获得机构审查委员会批准和知情同意后，对计划进行乳腺活检的妇女进行前瞻性试点评估。所有受试者数据的处理都符合HIPAA下有关受保护健康信息隐私和安全的规则和条例。该研究包括17名女性（平均年龄53岁，年龄范围44-67岁）和21个活检样本病变。将21例病变的DMT扫描结果与组织病理学结果进行比较。结果21例病变中，恶性7例，良性14例。在13例各有1个病变的患者中，3例活检结果阳性，10例活检结果阴性。4例有2个病变的患者，活检结果如下：双侧1例，均为阴性；双边在一，双方都积极；两组单侧，一组阳性，一组阴性。DMT扫描的敏感性为86%，特异性为100%，阳性预测值为100%，阴性预测值为93%，准确率为95%。结论对DMT扫描仪的初步临床评价表明，DMT扫描仪是一种可行、准确的检测和诊断乳腺癌的方法。像DMT扫描仪这样专门为三维多模态乳房成像设计的系统，可以使肿瘤检测、定位和乳腺癌特征的一些进展成为可能，这些进展目前正在用全身三维混合系统进行观察，如正电子发射断层扫描/计算机断层扫描（CT）或单光子发射计算机断层扫描/CT。©rsna, 2010
PurposeTo evaluate the clinical performance of a hybrid scanner that uses dual-modality tomosynthesis (DMT) and technetium 99m sestamibi to provide coregistered anatomic and functional breast images in three dimensions.Materials and MethodsA prospective pilot evaluation of the scanner was performed in women scheduled to undergo breast biopsy after institutional review board approval and informed consent were obtained. All subject data were handled in compliance with the rules and regulations concerning the privacy and security of protected health information under HIPAA. The study included 17 women (mean age, 53 years; age range, 44–67 years) and 21 biopsy-sampled lesions. Results of DMT scanning were compared with histopathologic results for the 21 lesions.ResultsOf the 21 lesions, seven were malignant, and 14 were benign. Among the 13 subjects with one lesion each, three had positive biopsy results, and 10 had negative biopsy results. Among the four subjects with two lesions, the biopsy results were as follows: bilateral in one, both negative; bilateral in one, both positive; unilateral in two, one positive and one negative. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of DMT scanning were 86%, 100%, 100%, 93%, and 95%, respectively.ConclusionPilot clinical evaluation of the DMT scanner suggests that it is a feasible and accurate method with which to detect and diagnose breast cancer. Systems such as the DMT scanner that are designed specifically for three-dimensional multimodality breast imaging could make possible some of the advances in tumor detection, localization, and characterization of breast cancer that are now being observed with whole-body three-dimensional hybrid systems, such as positron emission tomography/computed tomography (CT) or single photon emission computed tomography/CT.© RSNA, 2010