Genes that mediate breast cancer metastasis to lung
Genes that mediate breast cancer metastasis to lung
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DOI：
10.1038/nature03799
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发表时间：
2005-07-28
期刊：
影响因子：
64.8
通讯作者：
Massagué, J
中科院分区：
文献类型：
--
作者：
Minn, AJ;Gupta, GP;Massagué, J
通过体内筛选、转录分析、功能验证和临床验证，我们鉴定了一组标记和介导乳腺癌转移到肺部的基因。其中一些基因具有双重功能，在原发肿瘤和肺微环境中都提供了生长优势。另一些则选择性地促进了肺部的侵略性生长。许多基因编码细胞外蛋白，与癌症转移之间存在未知的相关性。
By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.