Biomolecular diffusional association
Biomolecular diffusional association
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DOI：
10.1016/s0959-440x(02)00311-1
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发表时间：
2002-04-01
影响因子：
6.8
通讯作者：
Wade, RC
中科院分区：
文献类型：
--
作者：
Gabdoulline, RR;Wade, RC
生物分子扩散缔合计算研究的主要方法是布朗动力学。最近的工作在计算关联率的效率和模拟模型的准确性方面取得了进步。布朗动力学应用的新领域包括蛋白质聚合和蛋白质表面吸附。最近对蛋白质-蛋白质关联和布朗动力学以及其他理论和实验方法进行了特别深入的研究，使人们对蛋白质-蛋白质结合动力学的决定因素有了新的认识。
The primary method for the computational study of biomolecular diffusional association is Brownian dynamics. Recent work has seen advances in the efficiency of computing association rates and in the accuracy of simulation models. New areas to which Brownian dynamics has been applied include protein polymerisation and protein adsorption to a surface. There has recently been particularly intense study of protein-protein association, and Brownian dynamics, together with other theoretical and experimental approaches, has led to new insights into the determinants of protein-protein binding kinetics.