Correction factor for the estimation of plasma glucose synthesis from the transfer of 14C-atoms from labelled substrate in vivo: A preliminary report.
Correction factor for the estimation of plasma glucose synthesis from the transfer of 14C-atoms from labelled substrate in vivo: A preliminary report.
复制标题
用于估计体内标记底物 14C 原子转移的血浆葡萄糖合成的校正因子：初步报告。
DOI：
10.1139/y79-119
复制
发表时间：
1979
影响因子：
2.1
通讯作者：
G. Hetenyi
中科院分区：
文献类型：
--
作者：
G. Hetenyi
基于先前设计的方法，用于估计乙酰辅酶A对肝脏草酰乙酸池的C原子贡献，在正常和糖尿病犬和正常大鼠中估计了由于“代谢交换”导致的从前体到血浆葡萄糖的14 C原子的损失。由于14 C-原子的这种损失，当从前体（甘油除外）转移14 C-原子计算时，正常犬中14 C-原子的转移率被低估了2.2 +/- 0.07，糖尿病犬中1.8 +/- 0.05，正常大鼠中1.55 +/- 0.04。
Based on a previously designed method for the estimation of the contribution of C-atoms by acetylcoenzyme A to the hepatic oxaloacetate pool, the loss of 14C-atoms on their way from a precursor to plasma glucose due to 'metabolic exchange' was estimated in normal and diabetic dogs and in normal rats. Due to this loss of 14C-atoms, the rates of gluconeogenesis when calculated from the transfer of 14C-atoms from precursors (other than glycerol) are underestimated by a factor of 2.2 +/- 0.07 in normal, 1.8 +/- 0.05 in diabetic dogs, and by 1.55 +/- 0.04 in normal rats.